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Titolo:
Newly developed drug delivery system in cancer chemotherapy using direct electric current
Autore:
Ito, K; Wong, L; Ando, HY; Hibi, K; Hidemura, K; Yamazaki, T; Kasai, Y; Akiyama, S; Nakao, A; Ikeda, S;
Indirizzi:
Nagoya Univ, Sch Med, Dept Surg 2, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Nagoya Inst Technol, Nagoya, Aichi, Japan Nagoya Inst Technol Nagoya Aichi Japan nst Technol, Nagoya, Aichi, Japan
Titolo Testata:
ASAIO JOURNAL
fascicolo: 4, volume: 47, anno: 2001,
pagine: 338 - 341
SICI:
1058-2916(200107/08)47:4<338:NDDDSI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHOTREXATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, K Nagoya Univ, Sch Med, Dept Surg 2, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsurumai Cho Nagoya Aichi Japan 4668550 68550, Japan
Citazione:
K. Ito et al., "Newly developed drug delivery system in cancer chemotherapy using direct electric current", ASAIO J, 47(4), 2001, pp. 338-341

Abstract

To improve the antitumor effect of chemotherapy on a target organ, we experimentally investigated pharmacokinetic alteration of methotrexate (MTX) induced by an electric current in rats to ascertain whether the local concentration of MTX could be enhanced while reducing the concentration in blood. Six male Wistar rats had platinum electrodes introduced into both kidneys. Three rats were subjected to direct current (3.5 V, 50 muA) for 3 hours, while another three control rats received no current. While providing the current to the treated group, all of the rats were intravenously injected withMTX at a dose of 1 mg/kg. The MTX concentration in urine (excreted from each ureter) and serum was measured by fluorescence polarization immunoassay. Cumulative MIX renal excretion rate was significantly higher in the cathode than anode side in the treated group (p < 0.01). Serum MTX concentration at 0 to 5 min was significantly reduced in the treated group (p < 0.03). The first part of the area under the curve (i.e., alpha curve) was markedly increased in the treated group versus controls (p = 0.05). Electric therapy using a slight direct current could gather anionized MTX to the cathode, while reducing MTX concentration in the serum of experimental rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:55:34