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Titolo:
Effect of prolonged selective intramesenteric arterial vasodilator therapyon intestinal viability after acute segmental mesenteric vascular occlusion
Autore:
Meilahn, JE; Morris, JB; Ceppa, EP; Bulkley, GB;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 t Surg, Baltimore, MD 21205 USA
Titolo Testata:
ANNALS OF SURGERY
fascicolo: 1, volume: 234, anno: 2001,
pagine: 107 - 115
SICI:
0003-4932(200107)234:1<107:EOPSIA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLATERAL BLOOD-FLOW; CARDIOGENIC-SHOCK; ISCHEMIA; MANAGEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bulkley, GB Johns Hopkins Hosp, Blalock 685,600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Hosp Blalock 685,600 N Wolfe St Baltimore MD USA 21287
Citazione:
J.E. Meilahn et al., "Effect of prolonged selective intramesenteric arterial vasodilator therapyon intestinal viability after acute segmental mesenteric vascular occlusion", ANN SURG, 234(1), 2001, pp. 107-115

Abstract

ObjectiveTo evaluate the effect of selective intramesenteric artery vasodilator infusion on intestinal viability in a rat model of acute segmental mesenteric vascular occlusion. Summary Background DataAlthough intramesenteric arterial vasodilator infusion may be an effectivetreatment for nonocclusive mesenteric ischemia, it has also been advocatedto increase collateral blood flow after mesenteric vascular occlusion, However, the authors have previously found that intraarterial vasodilators actually reduce collateral blood flow acutely, by preferentially dilating the vasculature of adjacent, nonischemic mesenteric vascular beds, a phenomenonwell established in other organs. MethodsA segment of rat ileum was acutely devascularized, with blood flow provided only by collateral arterial vessels from adjacent, nonischemic bowel, Papaverine (30 or 40 mug/kg/min), isoproterenol (0.06 mug/kg/min), norepinephrine (0.1 or 0.2 mug/kg/min), or vehicle saline was continuously infused into the cranial (superior) mesenteric artery for 48 hours. Viability was thenassessed using previously established, objective gross and microscopic criteria. ResultsAlthough papaverine increased total mesenteric blood flow in normally vascularized rats, it not only failed to improve but actually significantly reduced the length of lire devascularized segment maintained viable by collateral blood flow after 48 hours. isoproterenol had a similar effect. Norepinephrine infusion decreased both normal mesenteric blood flow acid viable segment length,ConclusionsThese findings suggest that intraarterial vasodilator therapy fails to improve intestinal viability after segmental mesenteric vascular occlusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:27:48