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Titolo:
Metabolism of atherogenic lipoproteins
Autore:
Beucler, I; Turpin, G;
Indirizzi:
Grp Hosp Pitie Salpetriere, Serv Biochim Med, Lab Lipides, F-75651 Paris 13, France Grp Hosp Pitie Salpetriere Paris France 13 des, F-75651 Paris 13, France Grp Hosp Pitie Salpetriere, Serv Endocrinol Metab, F-75651 Paris, France Grp Hosp Pitie Salpetriere Paris France F-75651 b, F-75651 Paris, France
Titolo Testata:
ANNALES DE MEDECINE INTERNE
fascicolo: 3, volume: 152, anno: 2001,
pagine: 158 - 161
SICI:
0003-410X(200104)152:3<158:MOAL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
FRE
Soggetto:
HIGH-DENSITY-LIPOPROTEINS; CORONARY-ARTERY DISEASE; HEART-DISEASE; CHOLESTEROL; IDENTIFICATION; TRIGLYCERIDE; TRANSPORT; RECEPTOR;
Keywords:
atherosclerosis; lipoproteins; TGRL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Beucler, I Grp Hosp Pitie Salpetriere, Serv Biochim Med, Lab Lipides, F-75651 Paris 13, France Grp Hosp Pitie Salpetriere Paris France 13 1 Paris 13, France
Citazione:
I. Beucler e G. Turpin, "Metabolism of atherogenic lipoproteins", ANN MED IN, 152(3), 2001, pp. 158-161

Abstract

Early development of atherosclerosis results from a complex multifactorialprocess where lipoprotein anomalies play a predominant role. The metabolism of lipoproteins is regulated by numerous reactions between the structuralcomponents of the lipoproteins and the receptors and/or enzymes with whichthey interact, Among the well-characterized anomalies, the elevation of small and dense LDL and/or the diminution of HDL levels are in First line of the factors involved in the formation of atheromatous plaques. LDL play a direct role by penetrating the intima or the arteries and HDL play an reverse transport of cholesterol from cells to the liver, There has been a long debate concerning risk related to triglyceride rich lipoproteins (TGRL), andmore particularly the increase in VLDL, However, a large number of studieshave demonstrated that these ephemeral lipoproteins can acquire major atherogenic potential when their level is increased and/or they are associated with perturbed metabolism leading to an accumulation of remnants. Current investigation methods have shown that LDL and HDL-cholesterol levels are excellent markers of LDL and HDL concentrations, Inversely, triglyceride levels provide little information concerning the nature of the elevated TGRL and lasting hypertriglyceridemia, even If moderate, should thereforebe considered as a warning sign of persistent atherogeneous remnants in the fasting state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 11:35:51