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Titolo:
Involvement of free radicals in MDMA-induced neurotoxicity in mice
Autore:
Cadet, JL; Thiriet, N; Jayanthi, S;
Indirizzi:
NIDA, Mol Neuropsychait Sect, NIH, Div Intramural Res, Baltimore, MD 21224USA NIDA Baltimore MD USA 21224 H, Div Intramural Res, Baltimore, MD 21224USA
Titolo Testata:
ANNALES DE MEDECINE INTERNE
, volume: 152, anno: 2001, supplemento:, 3
pagine: S57 - S59
SICI:
0003-410X(200104)152:<S57:IOFRIM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLENEDIOXYMETHAMPHETAMINE MDMA; SUPEROXIDE-DISMUTASE; TRANSGENIC MICE; ECSTASY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; HUMANS; BRAIN;
Keywords:
MDMA; drug abuse; toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Cadet, JL NIDA, Mol Neuropsychait Sect, NIH, Div Intramural Res, Baltimore, MD 21224USA NIDA Baltimore MD USA 21224 ramural Res, Baltimore, MD 21224USA
Citazione:
J.L. Cadet et al., "Involvement of free radicals in MDMA-induced neurotoxicity in mice", ANN MED IN, 152, 2001, pp. S57-S59

Abstract

3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a substituted amphetamine with stimulating and hallucinogenic properties, Administration of MDMA leads to the formation of metabolites responsible for its toxic effects on serotonergic neurons in rats and non-human primates and on dopaminergic neurons in mice. Our findings indicate that overexpression of the human superoxide dismutase gene (Cu/Zn-SOD) abolishes certain effects of MDMA such as the decreased level of dopamine, DOPAC and 5-HT in the striatum, inactivation of certain antioxidant enzymes (Cu/Zn-SPD, catalase or glutathione peroxidase) or peroxidation of lipids. These data are in agreement with the implication of free radicals and consequently of oxidative stress in the modeof action of MDMA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:12:23