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Titolo:
Erythrocyte margination and sedimentation in skeletal muscle venules
Autore:
Bishop, JJ; Nance, PR; Popel, AS; Intaglietta, M; Johnson, PC;
Indirizzi:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ioengn, La Jolla, CA 92093 USA Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 d Engn, Baltimore, MD 21205 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: H951 - H958
SICI:
0363-6135(200108)281:2<H951:EMASIS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT RHEOLOGICAL BEHAVIOR; ARTERIAL-PRESSURE REDUCTION; APPARENT VISCOSITY; VERTICAL TUBES; HUMAN-BLOOD; LOW SHEAR; FLOW; DIAMETER; VOLUME;
Keywords:
venous resistance; low shear flow; in vivo blood rheology; blood sludging; red blood cell core;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, PC Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 olla, CA 92093 USA
Citazione:
J.J. Bishop et al., "Erythrocyte margination and sedimentation in skeletal muscle venules", AM J P-HEAR, 281(2), 2001, pp. H951-H958

Abstract

Previous studies in skeletal muscle of the dog and cat have shown that venous vascular resistance changes inversely with blood flow and may be due mainly to red blood cell aggregation, a phenomenon present in these species. To determine whether red blood cell axial migration and sedimentation contribute to this effect, we viewed either vertically or horizontally oriented venules of the rat spinotrapezius muscle with a horizontally oriented microscope during acute arterial pressure reduction. With normal (nonaggregating) rat blood, reduction of arterial pressure did not significantly change the relative diameter of the red blood cell column with respect to the venular wall. After induction of red blood cell aggregation in the rat by infusion of Dextran 500, red blood cell column diameter decreased up to 35% at lowpseudoshear rates (below similar to5 s(-1)); the magnitude was independentof venular orientation. In vertically oriented venules, the plasma layer was symmetrical, whereas in horizontally oriented venules, the plasma layer formed near the upper wall. We conclude that, although red blood cell axialmigration and sedimentation develop in vivo, they occur only for larger flow reductions than are needed to elicit changes in venous resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 16:38:15