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Titolo:
Effects of erythrocyte aggregation and venous network geometry on red blood cell axial migration
Autore:
Bishop, JJ; Popel, AS; Intaglietta, M; Johnson, PC;
Indirizzi:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ioengn, La Jolla, CA 92093 USA Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 d Engn, Baltimore, MD 21205 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: H939 - H950
SICI:
0363-6135(200108)281:2<H939:EOEAAV>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT RHEOLOGICAL BEHAVIOR; ARTERIAL-PRESSURE REDUCTION; SKELETAL-MUSCLE VENULES; APPARENT VISCOSITY; VERTICAL TUBES; LOW SHEAR; FLOW; MICROVESSEL; DIAMETER; RESISTANCE;
Keywords:
venous resistance; radial migration; red blood cell aggregation; in vivo fluorescence microscopy; venous network topology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, PC Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 olla, CA 92093 USA
Citazione:
J.J. Bishop et al., "Effects of erythrocyte aggregation and venous network geometry on red blood cell axial migration", AM J P-HEAR, 281(2), 2001, pp. H939-H950

Abstract

Axial migration of red blood cells in small glass tubes can cause blood viscosity to be effectively independent of shear rate. However, this phase separation may not occur to the same degree in the venous network due to infusion of cells and aggregates at branch points. To investigate this hypothesis, we followed trajectories of fluorescently labeled red blood cells in the venular network of the rat spinotrapezius muscle at normal and reduced flow with and without red blood cell aggregation. Cells traveling near the wall of an unbranched venular segment migrated similar to1% of the longitudinal path length without aggregation and migrated slightly more with aggregation. Venular segment length between branch points averaged three to five times the diameter. Cells in the main vessel were shifted centrally by up to 20% of diameter at branch points, reducing the migration rate of cells nearthe opposite wall to <1% even in the presence of aggregation. We conclude that formation of a cell-free marginal layer in the venular network is attenuated due to the time dependence of axial migration and the frequent branching of the network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:42:23