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Titolo:
Differences in the dynamic cerebrovascular response between stepwise up tilt and down tilt in humans
Autore:
Sato, J; Tachibana, M; Numata, T; Nishino, T; Konno, A;
Indirizzi:
Chiba Univ, Sch Med, Dept Anesthesiol, Chuo Ku, Chiba 2608670, Japan ChibaUniv Chiba Japan 2608670 nesthesiol, Chuo Ku, Chiba 2608670, Japan Chiba Univ, Sch Med, Dept Otolaryngol, Chuo Ku, Chiba 2608670, Japan ChibaUniv Chiba Japan 2608670 tolaryngol, Chuo Ku, Chiba 2608670, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: H774 - H783
SICI:
0363-6135(200108)281:2<H774:DITDCR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; TRANSCRANIAL DOPPLER RECORDINGS; CRITICAL CLOSING PRESSURE; CARDIOVASCULAR-RESPONSES; AUTOREGULATION DYNAMICS; POTASSIUM CHANNELS; AUTONOMIC FAILURE; AUTO-REGULATION; VELOCITY; CIRCULATION;
Keywords:
blood flow velocity; step response; mathematical model; Doppler ultrasound;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Sato, J Chiba Univ, Sch Med, Dept Anesthesiol, Chuo Ku, 1-8-1 Ino Hana, Chiba 2608670, Japan Chiba Univ 1-8-1 Ino Hana Chiba Japan 2608670 hiba 2608670, Japan
Citazione:
J. Sato et al., "Differences in the dynamic cerebrovascular response between stepwise up tilt and down tilt in humans", AM J P-HEAR, 281(2), 2001, pp. H774-H783

Abstract

We studied dynamic cerebrovascular responses in eight healthy humans during repetitive stepwise upward tilt (SUT) and stepwise downward tilt (SDT) maneuvers between supine and 70 degrees standing at intervals of 60 s. Mean cerebral blood flow velocity (FVMCA) was measured at the middle cerebral artery (MCA) with transcranial Doppler ultrasonography. Mean arterial blood pressure (ABP) was measured via the radial artery and adjusted at the level of the MCA (ABP(MCA)). Cerebral critical closing pressure (P-CC) was estimated from the systolic-diastolic relationship between FVMCA and ABP(MCA). ABP(MCA) minus P-CC was considered the cerebral perfusion pressure (CPP). The tilt maneuvers produced stepwise changes in both CPP and FVMCA. The FVMCA response to SUT was well characterized by a linear second-order model. However, that to SDT presented a biphasic behavior that was described significantly better (P< 0.05) by the addition of a slowly responding component to the second-order model. This difference may reflect both different cardiovascular responses to SUT or SDT and different cerebrovascular autoregulatory behaviors in response to decreases or increases in CPP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:42:53