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Titolo:
Characterization of effects of endothelin-1 on the L-type Ca2+ current in human atrial myocytes
Autore:
Boixel, C; Dinanian, S; Lang-Lazdunski, L; Mercadier, JJ; Hatem, SN;
Indirizzi:
Fac Med Xavier Bichat, INSERM, U460, F-75018 Paris, France Fac Med Xavier Bichat Paris France F-75018 , U460, F-75018 Paris, France Hop Antoine Beclere, Serv Cardiol, F-92141 Clamart, France Hop Antoine Beclere Clamart France F-92141 diol, F-92141 Clamart, France Assistance Publ Hop Paris, Grp Hosp Bichat Claude Bernard, Serv Physiol Explorat Fonct, F-75018 Paris, France Assistance Publ Hop Paris Paris France F-75018 ct, F-75018 Paris, France Assistance Publ Hop Paris, Grp Hosp Bichat Claude Bernard, Serv Chirurg Cardiaque, F-75018 Paris, France Assistance Publ Hop Paris Paris France F-75018 ue, F-75018 Paris, France
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: H764 - H773
SICI:
0363-6135(200108)281:2<H764:COEOEO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CONGESTIVE-HEART-FAILURE; VENTRICULAR MYOCYTES; CALCIUM CURRENT; VASOCONSTRICTOR PEPTIDE; TRANSIENT OUTWARD; CARDIAC MYOCYTES; RECEPTORS; CELLS; RAT;
Keywords:
human cardiac cells; whole cell patch clamp;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Hatem, SN Fac Med Xavier Bichat, INSERM, U460, 16 Rue Henri Huchard, F-75018 Paris, France Fac Med Xavier Bichat 16 Rue Henri Huchard Paris France F-75018
Citazione:
C. Boixel et al., "Characterization of effects of endothelin-1 on the L-type Ca2+ current in human atrial myocytes", AM J P-HEAR, 281(2), 2001, pp. H764-H773

Abstract

The effects of endothelin-1 (ET-1) on the L-type Ca2+ current (I-Ca) were examined in whole cell patch-clamped human atrial myocytes. Depending on the initial current density, ET-1 (10 nM) increased the amplitude of I-Ca by 99 +/- 7% or decreased it by 33 +/- 2%. The stimulatory effect predominatedon current of low density (2.3 +/- 0.2 pA/ pF), whereas I-Ca of higher density (5.8 +/- 0.3 pA/ pF) was inhibited by ET-1. After I-Ca stimulation by 1 muM isoproterenol, ET-1 always inhibited the current by 32 +/- 7% (P< 0.05), an effect that was suppressed by pretreating myocytes with pertussis toxin. Atrial natriuretic peptide (ANP) inhibited I-Ca (41 +/- 3%) by reducing intracellular cAMP concentration. In ANP-treated myocytes, the stimulatory effect of ET-1 on I-Ca predominated (52 +/- 7%). The inhibitory effect ofET-1 on I-Ca was blocked by the ETA antagonist BQ-123, whereas the stimulatory effect was suppressed by the ETB agonist BQ-788. We conclude that ET-1has opposite effects on I-Ca depending on the baseline amplitude of current, and both subtype ET receptors are implicated in the signal transduction pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 06:52:12