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Titolo:
Fluvastatin inhibits O-2(-) and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload
Autore:
Katoh, M; Kurosawa, Y; Tanaka, K; Watanabe, A; Doi, H; Narita, H;
Indirizzi:
Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan Tanabe Seiyaku Co Ltd Toda Saitama Japan 3358505 , Saitama 3358505, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: H655 - H660
SICI:
0363-6135(200108)281:2<H655:FIOAIL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; NITRIC-OXIDE SYNTHESIS; VASCULAR SUPEROXIDE PRODUCTION; HMG-COA REDUCTASE; CONVERTING ENZYME; OXIDATIVE STRESS; CELL-ADHESION; 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION;
Keywords:
3-hydroxy-3-methylglutaryl CoA reductase inhibitor; superoxide anion; intercellular adhesion molecule-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, M Tanabe Seiyaku Co Ltd, Discovery Res Lab, 2-2-50 Kawagishi, Toda,Saitama 3358505, Japan Tanabe Seiyaku Co Ltd 2-2-50 Kawagishi Toda SaitamaJapan 3358505
Citazione:
M. Katoh et al., "Fluvastatin inhibits O-2(-) and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload", AM J P-HEAR, 281(2), 2001, pp. H655-H660

Abstract

Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression is suggested to play an important role in the pathogenesis of vascular remodeling. The aim of the present study was to investigate the effects of the 3-hydroxy-3-methylglutaryl (HMG) CoA reductase inhibitor fluvastatin on superoxide anion (O-2(-)) production and ICAM-1 expression in a rat model with vascular remodeling induced by pressure overload. Two weeks after aortic banding, marked increases in O-2(-) production and ICAM-1 protein levels were observed in the aorta. O-2(-) formation and ICAM-1 immunoreactivity were mainly increased in the endothelium and adventitia of the aorta in banded rats. Oral administration of fluvastatin prevented both these changes and the development of perivascular fibrosis and increased the expression of endothelial nitric oxide synthase. Cholesterol and lipid peroxide levels in serum did not change in the banded rats. Thus the beneficial effects of fluvastatin seen in this study as well as its cholesterol-lowering effect may contribute to attenuate the atherosclerotic process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 22:56:15