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Titolo:
Inotropic response of rabbit ventricular myocytes to endothelin-1: difference from isolated papillary muscles
Autore:
Talukder, MAH; Norota, I; Sakurai, K; Endoh, M;
Indirizzi:
Yamagata Univ, Sch Med, Dept Pharmacol, Yamagata 9909585, Japan Yamagata Univ Yamagata Japan 9909585 Pharmacol, Yamagata 9909585, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: H596 - H605
SICI:
0363-6135(200108)281:2<H596:IRORVM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II; RECEPTOR SUBTYPES; CA2+ TRANSIENT; PHARMACOLOGICAL ANALYSIS; INTRACELLULAR CA2+; NA+/H+ EXCHANGE; MYOCARDIUM; CONTRACTILITY; INHIBITION; HYDROLYSIS;
Keywords:
adult rabbit cardiomyocytes; cell shortening; Ca2+ transients; ETA receptor; ETB receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Endoh, M Yamagata Univ, Sch Med, Dept Pharmacol, 2-2-2 Iida Nishi, Yamagata 9909585, Japan Yamagata Univ 2-2-2 Iida Nishi Yamagata Japan 9909585 585, Japan
Citazione:
M.A.H. Talukder et al., "Inotropic response of rabbit ventricular myocytes to endothelin-1: difference from isolated papillary muscles", AM J P-HEAR, 281(2), 2001, pp. H596-H605

Abstract

Endothelin-1 (ET-1) increased cell shortening and Ca2+ transients over theconcentration of 3 x 3 10(-11) M to 10(-9) M with EC50 of 8.3 x 10(-11) M in rabbit single ventricular myocytes. Thus ET-1 was approximately 60 timesmore potent in single myocytes than in papillary muscles (EC50 = 5.1 x 10(-9) M) of the same species. In single myocytes, ET-1 at 10(-8) M elicited an inhibitory response that counteracted the facilitatory response: the concentration-response curve (CRC) for ET-1 was bell shaped. The ETA-receptor antagonist BQ-485 shifted CRC for ET-1 to the right in parallel; however, the facilitatory response to 10(-8) M ET-1 was markedly enhanced by BQ-485 and also by the ETB antagonist BQ-788. The ETA/ETB antagonist TAK-044 abolished the ET-1-induced response. These findings indicate that the response to ET-1 of single myocytes is different from that of papillary muscles in concentration dependence, characteristics of the response, and susceptibility to ET-receptor antagonists. Anomalous pharmacological characteristics of ET-1-induced response in rabbit papillary muscles may be due to integrated regulatory mechanisms that may involve also various types of noncardiac cell in ventricular myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:04:36