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Titolo:
Contrasting effects of phentolamine and nitroprusside on neural and cardiovascular variability
Autore:
Van de Borne, P; Rahnama, M; Mezzetti, S; Montano, N; Porta, A; Degaute, JP; Somers, VK;
Indirizzi:
Erasme Hosp, Hypertens Clin, Dept Cardiol, B-1070 Brussels, Belgium ErasmeHosp Brussels Belgium B-1070 pt Cardiol, B-1070 Brussels, Belgium Univ Milan, Osped L Sacco, Ctr Ric Cardiovasc,CNR, Dipartimento Sci Preclin Lab Interdisciplinaire T, I-20157 Milan, Italy Univ Milan Milan Italy I-20157 nterdisciplinaire T, I-20157 Milan, Italy Mayo Clin, Div Hypertens, Rochester, MN 55902 USA Mayo Clin Rochester MN USA 55902 , Div Hypertens, Rochester, MN 55902 USA Mayo Clin, Div Cardiovasc, Rochester, MN 55902 USA Mayo Clin Rochester MNUSA 55902 Div Cardiovasc, Rochester, MN 55902 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: H559 - H565
SICI:
0363-6135(200108)281:2<H559:CEOPAN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; R-R INTERVAL; SPECTRAL-ANALYSIS; BLOOD-PRESSURE; HEART-RATE; ARTERIAL-PRESSURE; CONSCIOUS RATS; MAYER WAVES; FREQUENCY; HUMANS;
Keywords:
sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Van de Borne, P Erasme Hosp, Hypertens Clin, Dept Cardiol, B-1070 Brussels, Belgium Erasme Hosp Brussels Belgium B-1070 70 Brussels, Belgium
Citazione:
P. Van de Borne et al., "Contrasting effects of phentolamine and nitroprusside on neural and cardiovascular variability", AM J P-HEAR, 281(2), 2001, pp. H559-H565

Abstract

The relative contributions of a central neural oscillator and of the delayin alpha -adrenergic transmission within the baroreflex loop in the predominance of low-frequency (LF) cardiovascular variability during sympathetic activation in humans are unclear. We measured R-R interval (RR), muscle sympathetic nerve activity (MSNA), blood pressure (BP), and their variability in 10 normal subjects during sympathetic activation achieved by BP loweringwith sodium nitroprusside (SNP) and alpha -adrenergic blockade using phentolamine. SNP and phentolamine induced comparable reductions in BP (P > 0.25). Despite tachycardia and sympathetic activation with both SNP and phentolamine, LF variability in RR, MSNA, and BP increased during SNP and decreased during phentolamine (SNP: RR +20 +/- 6%, MSNA +3 +/- 5%, systolic BP +9 +/- 6%, diastolic BP +7 +/- 5%; phentolamine: RR -2 +/- 7%, MSNA -34 +/- 6%,systolic BP -16 +/- 8%, diastolic BP -13 +/- 4%, P < 0.05 except systolic BP, where P = 0.09). Thus LF variability is reduced when sympathetic activation is induced by <alpha>-adrenergic blockade. This suggests that alpha -adrenergic transmission within the baroreflex loop may contribute importantly to the predominance of LF cardiovascular variability associated with sympathetic excitation in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:27:11