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Titolo:
Regional septal dysfunction in a three-dimensional computational model of focal myofiber disarray
Autore:
Usyk, TP; Omens, JH; McCulloch, AD;
Indirizzi:
Univ Calif San Diego, Dept Bioengn, Whitaker Inst Biomed Engn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 d Engn, La Jolla, CA 92093 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: H506 - H514
SICI:
0363-6135(200108)281:2<H506:RSDIAT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICLE; HYPERTROPHIC CARDIOMYOPATHY; TRANSGENIC MICE; CARDIAC-MUSCLE; ACTIVE CONTRACTION; SARCOMERE-LENGTH; MECHANICS; STRESS; MYOCARDIUM; EXPRESSION;
Keywords:
myocardial mechanics; angular dispersion; sarcomere length; finite-element method; MCL2v/ras; familial hypertrophic cardiomyopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: McCulloch, AD Univ Calif San Diego, Dept Bioengn, Whitaker Inst Biomed Engn, 9500 GilmanDr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 SA
Citazione:
T.P. Usyk et al., "Regional septal dysfunction in a three-dimensional computational model of focal myofiber disarray", AM J P-HEAR, 281(2), 2001, pp. H506-H514

Abstract

MLC2v/ras transgenic mice display a phenotype characteristic of hypertrophic cardiomyopathy, with septal hypertrophy and focal myocyte disarray. Experimental measurements of septal wall mechanics in ras transgenic mice have previously shown that regions of myocyte disarray have reduced principal systolic shortening, torsional systolic shear, and sarcomere length. To investigate the mechanisms of this regional dysfunction, a three-dimensional prolate spheroidal finite-element model was used to simulate filling and ejection in the hypertrophied mouse left ventricle with septal disarray. Focallydisarrayed septal myocardium was modeled by randomly distributed three-dimensional regions of altered material properties based on measured statistical distributions of muscle fiber angular dispersion. Material properties indisarrayed regions were modeled by decreased systolic anisotropy derived from increased fiber angle dispersion and decreased systolic tension development associated with reduced sarcomere lengths. Compared with measurements in ras transgenic mice, the model showed similar heterogeneity of septal systolic strain with the largest reductions in principal shortening and torsional shear in regions of greatest disarray. Average systolic principal shortening on the right ventricular septal surface of the model was -0.114 for normal regions and -0.065 for disarrayed regions; for torsional shear, these values were 0.047 and 0.019, respectively. These model results suggest that regional dysfunction in ras transgenic mice may be explained in part by the observed structural defects, including myofiber dispersion and reduced sarcomere length, which contributed about equally to predicted dysfunction in the disarrayed myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:13:19