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Titolo:
Intraglomerular metastasis from pancreatic cancer
Autore:
Yokoi, H; Nakata, M; Sawai, K; Yoshida, T; Koshikawa, M; Joyama, S; Tanaka, A; Goto, M; Ueda, S; Senzaki, H; Sugawara, A; Kuwahara, T;
Indirizzi:
Saiseikai Nakatsu Hosp, Dept Nephrol, Kita Ku, Osaka 5300012, Japan Saiseikai Nakatsu Hosp Osaka Japan 5300012 Kita Ku, Osaka 5300012, Japan Saiseikai Nakatsu Hosp, Dept Resp Med, Osaka 5300012, Japan Saiseikai Nakatsu Hosp Osaka Japan 5300012 esp Med, Osaka 5300012, Japan Saiseikai Nakatsu Hosp, Dept Pathol, Osaka 5300012, Japan Saiseikai Nakatsu Hosp Osaka Japan 5300012 Pathol, Osaka 5300012, Japan
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 6, volume: 37, anno: 2001,
pagine: 1299 - 1303
SICI:
0272-6386(200106)37:6<1299:IMFPC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; SIALYL LEWIS-A; VASCULAR ENDOTHELIUM; CELLS; ADHESION; NEPHROPATHY; CARCINOMA;
Keywords:
renal metastasis; granulocyte colony-stimulating factor (G-CSF)-producing pancreatic cancer; CA 19-9; tumor emboli; glomeruli; proliferating cell nuclear antigen (PCNA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kuwahara, T Saiseikai Nakatsu Hosp, Dept Nephrol, Kita Ku, 2-10-39 Shibata, Osaka 5300012, Japan Saiseikai Nakatsu Hosp 2-10-39 Shibata Osaka Japan 5300012 an
Citazione:
H. Yokoi et al., "Intraglomerular metastasis from pancreatic cancer", AM J KIDNEY, 37(6), 2001, pp. 1299-1303

Abstract

Few case reports have shown the presence of metastatic tumor cells in renal glomeruli. We report one case with intraglomerular metastasis proved at renal biopsy. A 60-year-old man suffered from weight loss and fever of unknown origin. Urinalysis revealed proteinuria with cellular and granular casts. Because vasculitis was suspected, renal biopsy was performed. Presence oftumor cells occupying the glomerular capillary lumina was shown by means of light microscopy and electron microscopy. Laboratory findings revealed elevated leukocyte count (28.9 x 10(3)/mm(3)), serum granulocyte colony-stimulating factor (G-CSF) (77 pg/mL), and serum CA 19-9 (21,885 U/mL). The patient soon developed disseminated intravascular coagulation and died. Autopsyfindings revealed pancreatic cancer showing positive staining for G-CSF and CA 19-9. Tumor cells in the glomerular capillary lumina showed positive staining for CA 19-9 and proliferating cell nuclear antigen (PCNA). These results suggest that the pancreatic tumor cells producing G-CSF were entrapped in the glomerular capillary lumina where they proliferated. This may havebeen the first step in renal metastasis. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:53:12