Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients
Autore:
Fodinger, M; Buchmayer, H; Heinz, G; Papagiannopoulos, M; Kletzmayr, J; Perschl, A; Vychytil, A; Horl, WH; Sunder-Plassmann, G;
Indirizzi:
Univ Vienna, Innere Med Klin 3, Klin Abt Nephrol & Dialyse, A-1090 Vienna,Austria Univ Vienna Vienna Austria A-1090 phrol & Dialyse, A-1090 Vienna,Austria Univ Vienna, Div Cardiol & Angiol, Dept Med 2, Vienna, Austria Univ Vienna Vienna Austria ardiol & Angiol, Dept Med 2, Vienna, Austria Univ Vienna, Dept Med 3, Div Nephrol & Dialysis, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 rol & Dialysis, A-1090 Vienna, Austria Univ Vienna, Dept Lab Med, Div Endocrinol & Metab, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 crinol & Metab, A-1090 Vienna, Austria Univ Vienna, Dept Med 3, Div Cardiol & Angiol, A-1090 Vienna, Austria UnivVienna Vienna Austria A-1090 rdiol & Angiol, A-1090 Vienna, Austria
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 1, volume: 38, anno: 2001,
pagine: 77 - 84
SICI:
0272-6386(200107)38:1<77:AOTMPW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLENETETRAHYDROFOLATE REDUCTASE GENE; NEURAL-TUBE DEFECTS; HEMODIALYSIS-PATIENTS; RISK FACTOR; FOLIC-ACID; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE; GRAFT RECIPIENTS; VASCULAR-DISEASE; COMMON MUTATION; RENAL-DISEASE;
Keywords:
5,10-methylenetetrahydrofolate reductase; (MTHFR); total homocysteine (tHcy); hemodialysis (HD); peritoneal dialysis (PD); folate; vitamin B-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Fodinger, M Univ Vienna, Innere Med Klin 3, Klin Abt Nephrol & Dialyse, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 tria
Citazione:
M. Fodinger et al., "Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients", AM J KIDNEY, 38(1), 2001, pp. 77-84

Abstract

The effect of the combined 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C -->T and 1298A -->C genotype on total homocysteine (tHcy), folate, and vitamin B-12 plasma levels was investigated in 983 subjects, including 415 hemodialysis patients, 179 peritoneal dialysis patients, and 389 healthyindividuals. Mean tHcy plasma concentrations were 27.2 +/- 15.8 mu mol/L in hemodlalysis patients, 25.4 +/- 19.1 mu mol/L in peritoneal dialysis patients, and 8.9 +/- 3.5 mu mol/L in healthy individuals. Hypyperhomocysteinemia (tHcy > 15 mu mol/L) was detected in 81.6% of patients and 2.6% of controls, Multiple stepwise regression analysis showed that the MTHFR 677C --> T/1298A -->C genotype (CC/AA, CC/AC, CC/CC, CT/AA, CT/AC, TT/AA), vitamin use, age, folate and vitamin B-12 plasma level were significant predictors oftHcy plasma levels. Analysis of variance showed that this effect of MTHFR genotypes on tHcy level was caused by significantly greater tHcy levels in 677TT/1298AA hemodialysis and peritoneal dialysis patients versus other genotypes, Compound heterozygous controls (677CT/1298AC genotype) had significantly greater tHcy levels compared with 677CC/1298AA controls. There was nomajor effect of MTHFR polymorphisms on folate and vitamin B-12 plasma concentrations. This study shows that the MTHFR 677TT/1298AA genotype, but not the 677CT/1298AC genotype, is a significant predictor of tHcy plasma levelsin dialysis patients. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:22:13