Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Renal implications of angiotensin receptor blockers
Autore:
Hollenberg, NK;
Indirizzi:
Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 7, volume: 14, anno: 2001,
parte:, 2 supplemento:, S
pagine: 237S - 241S
SICI:
0895-7061(200107)14:7<237S:RIOARB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; DEPENDENT DIABETES-MELLITUS; ACE GENE POLYMORPHISM; HEALTHY HUMANS; II ANTAGONIST; NEPHROPATHY; SYSTEM; PROGRESSION; COMPLICATIONS; HYPERGLYCEMIA;
Keywords:
angiotensin converting enzyme; angiotensin receptor blocker; end-stage renal disease; renin-angiotensin system; diabetic nephropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hollenberg, NK Brigham & Womens Hosp, 175 Francis St, Boston, MA 02115 USABrigham & Womens Hosp 175 Francis St Boston MA USA 02115 SA
Citazione:
N.K. Hollenberg, "Renal implications of angiotensin receptor blockers", AM J HYPERT, 14(7), 2001, pp. 237S-241S

Abstract

The role of the renin-angiotensin system (RAS) in the regulation of blood pressure and the pathogenesis of both hypertension and renal complications involves an intricate interplay of genetic and environmental factors. In the case of diabetic nephropathy, the genes governing the RAS are an obvious choice in the search for contributing factors. These genetic components canreflect polygenetic mechanisms or a major gene effect. During recent years, polymorphisms of the genes governing both angiotensin converting enzyme (ACE) and angiotensinogen have been studied, with varying outcomes. Investigation of the interaction between ACE inhibition and the glycemic state yields equally interesting results. In healthy subjects on a high saltdiet, the hyperglycemic state produced significant increases in renal plasma flow (RPF) in response to administration of the ACE inhibitor captopril,A similar study using the angiotensin receptor blocker (ARB) eprosartan demonstrated again that the agent had little effect on RPF in subjects in a normal glycemic state; however, when administered during a hyperglycemic state, a marked increase in RPF occurred. Implications for the prevention of nephropathy and endstage renal disease (ESRD) in diabetics with hypertensionare significant. Until recently, pharmacologic intervention in the RAS hasfocused on the ACE step, with documented success being reported in the prevention of diabetic nephropathy and ESRD using ACE inhibitors. Despite thissuccess, data suggest that greater therapeutic benefit might be accomplished by blocking the deleterious effects of angiotensin II at the receptor site. From a renoprotective perspective, the ARB appear to have tremendous potential in the management of hypertension. Am J Hypertens 2001;14:237S-241S(C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:32:37