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Titolo:
Critical regions for deubiquitinating activity of DUB-2 expressed in T-lymphocytes
Autore:
Lee, JH; Kim, YS; Kim, MY; Baek, KH;
Indirizzi:
Pochon CHA Univ, Coll Med, Infertil Med Ctr, CHA Gen Hosp,Dept Microbiol,Kangnam Gu, Seoul 135081, South Korea Pochon CHA Univ Seoul South Korea 135081 m Gu, Seoul 135081, South Korea
Titolo Testata:
AMERICAN JOURNAL OF HEMATOLOGY
fascicolo: 4, volume: 67, anno: 2001,
pagine: 270 - 272
SICI:
0361-8609(200108)67:4<270:CRFDAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYMES;
Keywords:
deubiquitination; DUB-1; DUB-2; ubiquitin; ubp;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Baek, KH Pochon CHA Univ, Coll Med, Infertil Med Ctr, CHA Gen Hosp,Dept Microbiol,Kangnam Gu, 606-5 Yeoksam 1 Dong, Seoul 135081, South Korea Pochon CHA Univ 606-5 Yeoksam 1 Dong Seoul South Korea 135081 ea
Citazione:
J.H. Lee et al., "Critical regions for deubiquitinating activity of DUB-2 expressed in T-lymphocytes", AM J HEMAT, 67(4), 2001, pp. 270-272

Abstract

Ubiquitin- and proteasome-mediated protein degradation is involved in manyintracellular processes, including cell cycle regulation, transcriptional activation, and signal transduction in all eukaryotes, Novel subfamily members of the ubp superfamily, DUB-1 and DUB-2, are known to be immediate-early genes and are specifically expressed in B-lymphocytes end T-lymphocytes, respectively. With the site-directed mutagenesis in four conserved amino acids (Cys60, Asp133, His298, and His307) and a series of deletion in the carboxy-terminal region, we demonstrate that these conserved amino acids are critical, but not the C-terminus, for the deubiquitinating activity of DUB-P, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:48:04