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Titolo:
Massive plasmocytosis due to methimazole-induced bone marrow toxicity
Autore:
Breier, DV; Rendo, P; Gonzalez, J; Shilton, G; Stivel, M; Goldztein, S;
Indirizzi:
Hosp Gen Agudos Carlos G Durand, Div Hematol, RA-1419 Buenos Aires, DF, Argentina Hosp Gen Agudos Carlos G Durand Buenos Aires DF Argentina RA-1419 gentina Hosp Gen Agudos Carlos G Durand, Dept Pediat, RA-1419 Buenos Aires, DF, Argentina Hosp Gen Agudos Carlos G Durand Buenos Aires DF Argentina RA-1419 gentina Hosp Gen Agudos Carlos G Durand, Div Endocrinol, RA-1419 Buenos Aires, DF,Argentina Hosp Gen Agudos Carlos G Durand Buenos Aires DF Argentina RA-1419 gentina
Titolo Testata:
AMERICAN JOURNAL OF HEMATOLOGY
fascicolo: 4, volume: 67, anno: 2001,
pagine: 259 - 261
SICI:
0361-8609(200108)67:4<259:MPDTMB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; DRUG-INDUCED AGRANULOCYTOSIS; SEVERE APLASTIC-ANEMIA; ANTITHYROID DRUGS; DOSE REGIMEN; GRANULOCYTE;
Keywords:
bone marrow suppression; methimazole; marrow hypoplasia; plasmocytosis; antithyroid drugs; adverse effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Breier, DV Hosp Gen Agudos Carlos G Durand, Div Hematol, Concordia 3650, RA-1419 Buenos Aires, DF, Argentina Hosp Gen Agudos Carlos G Durand Concordia 3650 Buenos Aires DF Argentina RA-1419
Citazione:
D.V. Breier et al., "Massive plasmocytosis due to methimazole-induced bone marrow toxicity", AM J HEMAT, 67(4), 2001, pp. 259-261

Abstract

Pancytopenia is a rare complication of the thionamide therapy reported secondary to aplastic anemia, the bone marrow being invariably hypocellular. We present a case of a 16-year-old female with Graves' disease who presentedwith massive bone marrow plasmocytosis mimicking multiple myeloma, The patient had already been on methimazole for a month when she was admitted to the Pediatric Unit with the diagnosis of sepsis, CBC revealed pancytopenia. Bone marrow aspirations showed hypocellular-normocellular bone marrow, 98% of plasma cells. At that time, MMI was discontinued and the patient was started on broad-spectrum antibiotics, dexamethasone, and G-CSF, Bone marrow aspiration day +4 stili showed hypo-normocellular marrow, with remaining 6% plasma cells. Myeloma screen was negative; ANC >1,000 at day +7, platelets,> 50,000 at day +24, Twenty-four months after patient's discharge, her clinical condition, CBC, and bone marrow remained normal. To our knowledge thisis the first report of pancytopenia due to MMI, where the usual hypoplasiafound is replaced by massive plasmocytosis, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:25:30