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Titolo:
Stability and compatibility of tirofiban hydrochloride during simulated Y-site administration with other drugs
Autore:
Bergquist, PA; Manas, D; Hunke, WA; Reed, RA;
Indirizzi:
Merck & Co Inc, Pharmaceut Dev, W Point, PA 19486 USA Merck & Co Inc W Point PA USA 19486 Pharmaceut Dev, W Point, PA 19486 USA Merck & Co Inc, Pharmaceut Anal & Control, W Point, PA 19486 USA Merck & Co Inc W Point PA USA 19486 Anal & Control, W Point, PA 19486 USA
Titolo Testata:
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
fascicolo: 13, volume: 58, anno: 2001,
pagine: 1218 - 1223
SICI:
1079-2082(20010701)58:13<1218:SACOTH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY;
Keywords:
anxiolytics; sedatives and hypnotics; dextrose; diazepam; diluents; incompatibilities; injections; platelet aggregation inhibitors; precipitation; sodium; chloride; stability; storage; tirofiban hydrochloride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Bergquist, PA Merck & Co Inc, Pharmaceut Dev, WP78-204,Sumneytown Pike, W Point, PA 19486 USA Merck & Co Inc WP78-204,Sumneytown Pike W Point PA USA 19486
Citazione:
P.A. Bergquist et al., "Stability and compatibility of tirofiban hydrochloride during simulated Y-site administration with other drugs", AM J HEAL S, 58(13), 2001, pp. 1218-1223

Abstract

The stability and compatibility of tirofiban hydrochloride injection during simulated Y-site administration with various other drugs were studied. Tirofiban hydrochloride, dobutamine, epinephrine hydrochloride, furosemide, midazolam hydrochloride, and propranolol hydrochloride injections were each prepared from their respective concentrates in both 0.9% sodium chlorideinjection and 5% dextrose injection at both the minimum and maximum concentrations normally administered. The high-concentration solutions of midazolam hydrochloride and furosemide were used as is. Morphine sulfate was diluted in 5% dextrose injection only. Nitroglycerin premixed infusions, atropine sulfate injection, and diazepam injection were used as is. Tirofiban hydrochloride solutions were combined 1:1 with each of the secondary drug solutions in separate glass containers. Samples were stored for four hours at room temperature under ambient fluorescent light and were assayed for drug content and degradation by highperformance liquid chromatography and for pH, appearance, and turbidity. All mixtures except those containing diazepam remained clear and colorless, with no visual or turbidimetric indication of physical instability. Mixing of tirofiban hydrochloride and diazepam solutions resulted in immediate precipitation. All remaining mixtures remained clear. There was no significant loss of any of the drugs tested, no increase in known degradation products, and no appearance of unknown drug-related peaks. The pH of all test solutions remained constant. Tirofiban hydrochloride injection 0.05 mg/mL was stable for at least four hours when combined 1:1 in glass containers with atropine sulfate, dobutamine, epinephrine hydrochloride, furosemide, midazolam hydrochloride, morphine sulfate, nitroglycerin, and propranolol hydrochloride at the concentrations studied. Tirofiban hydrochloride was incompatible with diazepam.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:36:44