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Titolo:
Usefulness of T-axis deviation as an independent risk indicator for incident cardiac events in older men and women free from coronary heart disease (The Cardiovascular Health Study)
Autore:
Rautaharju, PM; Nelson, JC; Kronmal, RA; Zhang, ZM; Robbins, J; Gottdiener, JS; Furberg, CD; Manolio, T; Fried, L;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27109 USAWake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Univ Washington, CHS Coordinating Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 rdinating Ctr, Seattle, WA 98195 USA Univ Calif Davis, Dept Med, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 pt Med, Sacramento, CA 95817 USA St Francis Hosp, Dept Cardiol, Roslyn, NY USA St Francis Hosp Roslyn NY USA Francis Hosp, Dept Cardiol, Roslyn, NY USA NHLBI, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, NIH, Bethesda, MD 20892 USA Johns Hopkins Univ, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 s Univ, Baltimore, MD 21218 USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 2, volume: 88, anno: 2001,
pagine: 118 - 123
SICI:
0002-9149(20010715)88:2<118:UOTDAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROCARDIOGRAPHIC ABNORMALITIES; ECG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Rautaharju, PM EPICARE Ctr, Suite 505,Piedmont Plaza 2,2000 W 1st St, Winston Salem, NC 27104 USA EPICARE Ctr Suite 505,Piedmont Plaza 2,2000 W 1st St Winston Salem NC USA 27104
Citazione:
P.M. Rautaharju et al., "Usefulness of T-axis deviation as an independent risk indicator for incident cardiac events in older men and women free from coronary heart disease (The Cardiovascular Health Study)", AM J CARD, 88(2), 2001, pp. 118-123

Abstract

T-axis shift has been reported to be an indicator of increased mortality risk. We evaluated the association of spatial T-axis deviation with incidentcoronary heart disease (CHD) events in older men and women h ee from clinically overt CHD. Spatial T-axis deviation was measured from the standard 12-lead electrocardiogram of a subgroup of 4,173 subjects considered free of CHD at baseline in the Cardiovascular Health Study, a prospective cohort study of risk factors for CHD and stroke in older men and women. Cox regression analysis was used to evaluate the associations of altered repolarizationwith the risk of incident CHD events. The prevalence of marked T-axis deviation (greater than or equal to 45 degrees) was 12%. During the median follow-up of 7.4 years, there were 161 CHD deaths, 743 deaths from all causes, and 679 incident CHD events. Adjusting for demographic and clinical risk factors, including other electrocardiographic abnormalities, there was a nearly twofold excess risk of CHD death, and approximately a 50% excess risk ofincident CHD and all-cause mortality for those with marked Taxis deviation. From other electrocardiographic abnormalities, only QT prolongation was associated with excess risk for incident CHD comparable to that for abnormalT-axis deviation. These results suggest that T-axis deviation is an easilyquantified marker for subclinical disease and an independent indicator forthe risk of incident CHD events in older men and women free of CHD. (C) 2001 by Excerpta Medica, Inc.

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Documento generato il 05/12/20 alle ore 09:47:36