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Titolo:
Alcohol-mediated purkinje cell loss in the absence of hypoxemia during thethird trimester in an ovine model system
Autore:
West, JR; Parnell, SE; Chen, WJA; Cudd, TA;
Indirizzi:
Texas A&M Univ, Hlth Sci Ctr, Dept Human Anat & Med Neurobiol, Coll Med, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 ll Med, College Stn, TX 77843 USA Texas A&M Univ, Coll Vet Med, Dept Vet Physiol & Pharmacol, College Stn, TX USA Texas A&M Univ College Stn TX USA ysiol & Pharmacol, College Stn, TX USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 7, volume: 25, anno: 2001,
pagine: 1051 - 1057
SICI:
0145-6008(200107)25:7<1051:APCLIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN GROWTH SPURT; MATERNAL ETHANOL INFUSION; TERM PREGNANT EWE; CEREBELLAR PURKINJE; BLOOD-FLOW; BINGE EXPOSURE; NEONATAL RATS; NEURONAL LOSS; FETAL; DAMAGE;
Keywords:
brain; cerebellum; development; fetal alcohol syndrome; sheep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: West, JR Texas A&M Univ, Hlth Sci Ctr, Dept Human Anat & Med Neurobiol, Coll Med, Reynolds Med Bldg,Rm 228, College Stn, TX 77843 USA Texas A&M Univ Reynolds Med Bldg,Rm 228 College Stn TX USA 77843
Citazione:
J.R. West et al., "Alcohol-mediated purkinje cell loss in the absence of hypoxemia during thethird trimester in an ovine model system", ALC CLIN EX, 25(7), 2001, pp. 1051-1057

Abstract

Background: Although the mechanisms that underlie fetal alcohol-induced neuronal loss have not been determined, hypoxia/hypoxemia has been considereda leading candidate; This study was designed to test the hypothesis that neuronal loss could occur in the developing brain in the absence of fetal hypoxemia. Methods: Three groups of pregnant sheep were used: a control group, a binge-drinking group, and a pair-fed group. The alcohol and pair-fed animals were anesthetized on day 113 of pregnancy, and the mothers and fetuses were instrumented with arterial and venous catheters. All animals were killed on day 133. Stereological cell counting techniques were used to estimate the total number of Purkinje cells in the fetal cerebellum. Results: Peak maternal and fetal blood alcohol concentrations did not produce fetal hypoxemia. Nevertheless, there was a 25% loss of Purkinje cells of the cerebellum in the alcohol-exposed fetuses compared with that in the pair-fed controls. The loss of neurons was not accompanied by microencephalyor a concomitant decrease in either cerebellar weight or volume of the fetal cerebellum. Conclusions: Neuronal loss can be observed after alcohol exposure during the third trimester equivalent in fetal sheep in the absence of alcohol-induced hypoxemia. Furthermore, cell loss in the absence of deficits in gross brain weight or regional brain volume indicates that the lack of gross brainvolume deficits from magnetic resonance imaging techniques is not a reliable indication that the brain is unaffected by the alcohol exposure.

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Documento generato il 01/04/20 alle ore 11:21:13