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Titolo:
Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers
Autore:
Whitfield, JB; Zhu, G; Heath, AC; Powell, LW; Martin, NG;
Indirizzi:
Royal Prince Alfred Hosp, Dept Clin Biochem, Sydney, NSW, Australia Royal Prince Alfred Hosp Sydney NSW Australia em, Sydney, NSW, Australia Univ Sydney, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia2006 Sydney, Sydney, NSW 2006, Australia Queensland Inst Med Res, Brisbane, Qld 4006, Australia Queensland Inst MedRes Brisbane Qld Australia 4006 , Qld 4006, Australia Univ Queensland, Joint Genet Program, St Lucia, Qld 4067, Australia Univ Queensland St Lucia Qld Australia 4067 St Lucia, Qld 4067, Australia Washington Univ, Dept Psychiat, Missouri Alcoholism Res Ctr, St Louis, MO USA Washington Univ St Louis MO USA uri Alcoholism Res Ctr, St Louis, MO USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 7, volume: 25, anno: 2001,
pagine: 1037 - 1045
SICI:
0145-6008(200107)25:7<1037:EOACOI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOHYDRATE-DEFICIENT TRANSFERRIN; PORPHYRIA-CUTANEA-TARDA; SERUM FERRITIN; LIVER IRON; HEPATITIS-C; BODY IRON; MEN; OVERLOAD; HEMOCHROMATOSIS; DEPENDENCE;
Keywords:
iron; ferritin; dependence; biological markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Whitfield, JB Royal Prince Alfred Hosp, Dept Biochem, Camperdown, NSW, Australia Royal Prince Alfred Hosp Camperdown NSW Australia ustralia
Citazione:
J.B. Whitfield et al., "Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers", ALC CLIN EX, 25(7), 2001, pp. 1037-1045

Abstract

Background: Alcohol increases body iron stores. Alcohol and iron may increase oxidative stress and the risk of alcohol-related liver disease. The relationship between low or "safe" levels of alcohol use and indices of body iron stores, and the factors that affect the alcohol-iron relationship, havenot been fully characterized. Other aspects of the biological response to alcohol use have been reported to depend on iron status. Methods: We have measured serum iron, transferrin, and ferritin as indicesof iron stores in 3375 adult twin subjects recruited through the Australian Twin Registry. Information on alcohol use and dependence and smoking was obtained from questionnaires and interviews. Results: Serum iron and ferritin increased progressively across classes ofalcohol intake. The effects of beer consumption were greater than those ofwine or spirits. Ferritin concentration was significantly higher in subjects who had ever been alcohol dependent. There was no evidence of interactions between HFE genotype or body mass index and alcohol. Alcohol intake-adjusted carbohydrate-deficient transferrin was increased in women in the lowest quartile of ferritin results, whereas adjusted gamma -glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase values were increased in subjects with high ferritin. Conclusions: Alcohol intake at low level increases ferritin and, by inference, body iron stores. This may be either beneficial or harmful, depending on circumstances. The response of biological markers of alcohol intake can be affected by body iron stores; this has implications for test sensitivityand specificity and for variation in biological responses to alcohol use.

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Documento generato il 05/04/20 alle ore 05:58:38