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Titolo:
Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice
Autore:
Zimatkin, SM; Liopo, AV; Satanovskaya, VI; Bardina, LR; Deitrich, RA;
Indirizzi:
Univ Colorado, Dept Pharmacol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 o, Dept Pharmacol, Denver, CO 80262 USA Grodno State Med Univ, Grodno, Byelarus Grodno State Med Univ Grodno Byelarus State Med Univ, Grodno, Byelarus Natl Acad Sci Belarus, Inst Biochem, Grodno, Byelarus Natl Acad Sci Belarus Grodno Byelarus s, Inst Biochem, Grodno, Byelarus
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 7, volume: 25, anno: 2001,
pagine: 982 - 988
SICI:
0145-6008(200107)25:7<982:ROBEMT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; ALDEHYDE DEHYDROGENASE-ACTIVITIES; GAMMA-AMINOBUTYRIC ACID; SHORT-SLEEP MICE; INBRED STRAINS; ALCOHOL-DEHYDROGENASE; CATALASE ACTIVITY; LONG-SLEEP; ACETALDEHYDE; 3-AMINO-1,2,4-TRIAZOLE;
Keywords:
brain ethanol metabolism; catalase; acetaldehyde; alcohol sensitivity; hypnotic effect of ethanol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Deitrich, RA Univ Colorado, Dept Pharmacol, 4200 E 9th Ave,Box C236, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave,Box C236 Denver CO USA 80262 USA
Citazione:
S.M. Zimatkin et al., "Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice", ALC CLIN EX, 25(7), 2001, pp. 982-988

Abstract

Background: To clarify the role of brain acelaldehyde in the hypnotic effect of ethanol, we compared the ethanol-oxidizing capacity (rate of acetaldehyde accumulation) and catalase and aldehyde dehydrogenase activity in the brains of animals genetically selected for different sensitivities to the hypnotic effect of ethanol. Methods: We used high, low, or control alcohol-sensitive rats (HAS, LAS, and GAS) and short- and long-sleep mice (SS and LS), as well as SS X LS recombinant inbred mice with known strain differences in mean duration of ethanol-induced sleep. We studied the rate of accumulation of acetaldehyde from ethanol in brain homogenates of these animals and correlated those values with their hypnotic sensitivity to ethanol. Results: Acetaldehyde accumulation from ethanol was significantly higher in the brain homogenates from HAS rats and LS mice with high sensitivity to the hypnotic effect of ethanol in vivo, compared with LAS rats and SS mice with low sensitivity to ethanol. A correlation was found between the duration of ethanol-induced sleep and the in vitro rate of accumulation of ethanol-derived acetaldehyde in the brains of recombinant SS X LS mice strains. There was no correlation of sleep time with brain catalase levels. There were no line differences in brain catalase or aldehyde dehydrogenase or in alcohol or aldehyde dehydrogenase activity in livers of LAS, GAS, and HAS ratsor in SS and LS mice. Conclusions: A correlation between the brain acetaldehyde accumulation, but not catalase levels, and the central effect of ethanol was demonstrated in animals genetically differing in initial sensitivity to the hypnotic effect of ethanol.

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Documento generato il 20/01/20 alle ore 10:29:33