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Titolo:
P3 event-related potential, dopamine D2 receptor A1 allele, and sensation-seeking in adult children of alcoholics
Autore:
Ratsma, JE; van der Stelt, O; Schoffelmeer, ANM; Westerveld, A; Gunning, WB;
Indirizzi:
Univ Amsterdam, Acad Ctr Child & Adolescent Psychiat, NL-1100 AL Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1100 AL L Amsterdam, Netherlands Univ Amsterdam, Dept Psychon, NL-1100 AL Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1100 AL L Amsterdam, Netherlands Univ Amsterdam, Dept Human Genet, NL-1100 AL Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1100 AL L Amsterdam, Netherlands Vrije Univ Amsterdam, Drug Abuse Program, Neurosci Res Inst, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands Inst, Amsterdam, Netherlands Vrije Univ Amsterdam, Med Ctr, Dept Pharmacol, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands acol, Amsterdam, Netherlands
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 7, volume: 25, anno: 2001,
pagine: 960 - 967
SICI:
0145-6008(200107)25:7<960:PEPDDR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILY HISTORY; YOUNG-ADULTS; VISUAL P3; HIGH-RISK; NOVELTY; PREDISPOSITION; AMPLITUDE; MARKER; PERSONALITY; ASSOCIATION;
Keywords:
P3 ERP; dopamine D2 receptor gene; sensation-seeking; alcoholism risk; children of alcoholics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Ratsma, JE Univ Amsterdam, Acad Ctr Child & Adolescent Psychiat, POB 12474, NL-1100 AL Amsterdam, Netherlands Univ Amsterdam POB 12474 Amsterdam Netherlands NL-1100 AL ands
Citazione:
J.E. Ratsma et al., "P3 event-related potential, dopamine D2 receptor A1 allele, and sensation-seeking in adult children of alcoholics", ALC CLIN EX, 25(7), 2001, pp. 960-967

Abstract

Background: Research has indicated a close relationship between the P3 event-related potential and the dopamine D2 receptor Al allele in individuals at high risk for alcoholism. Other research has suggested an association between the dopamine D2 receptor A1 allele and sensation-seeking. In this study, we further examined the relationships between the P3, the A1 allele, and sensation-seeking in a sample of nonalcoholic adult children of alcoholics. Methods: Participants (n = 57; range, 19-30 years; 41 women), who performed a visual novelty oddball task to elicit the P3, were asked to fill in personality questionnaires, including Zuckerman's Sensation-Seeking Scale, andwere classified according to the presence of the dopamine D2 receptor A1 allele. The effects of sex, age, and socioeconomic status were assessed to determine whether these variables affected the relations between the P3, theA1 allele, and sensation-seeking. Results: A small P3 amplitude was associated with high sensation-seeking, particularly with high disinhibition. The presence of the A1 allele was also associated with high disinhibition, but only in men. By contrast, P3 amplitudes and latencies were not associated with the presence of the A1 allele. Conclusions: Although a small P3 amplitude, high sensation-seeking, and the presence of the A1 allele were all associated with alcoholism risk, thesefindings indicate that these three characteristics together do not reflecta common risk factor in alcoholism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:10:02