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Titolo:
The clinical course of alcohol dependence associated with a low level of response to alcohol
Autore:
Schuckit, MA; Smith, TL;
Indirizzi:
Vet Affairs San Diego Healthcare Syst, Dept Psychiat 116A, San Diego, CA 92161 USA Vet Affairs San Diego Healthcare Syst San Diego CA USA 92161 CA 92161 USA
Titolo Testata:
ADDICTION
fascicolo: 6, volume: 96, anno: 2001,
pagine: 903 - 910
SICI:
0965-2140(200106)96:6<903:TCCOAD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRINKING PROBLEMS; SUBSTANCE-ABUSE; FOLLOW-UP; HIGH-RISK; MEN; DISORDERS; SONS; HISTORY; WOMEN; SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Schuckit, MA Univ Calif San Diego, 3350 La Jolla Village Dr, San Diego, CA92161 USA Univ Calif San Diego 3350 La Jolla Village Dr San Diego CA USA 92161
Citazione:
M.A. Schuckit e T.L. Smith, "The clinical course of alcohol dependence associated with a low level of response to alcohol", ADDICTION, 96(6), 2001, pp. 903-910

Abstract

Aims. To evaluate the clinical course of specific alcohol-related life problems and the risk for dependence on illicit drugs in individuals with relatively low and high levels of response (LR) to alcohol earlier in life. Subjects. From among 439 men who were part of the 15-year follow-up of sons ofalcoholics and controls, 108 were identified as having fulfilled criteria for DSM-III-R alcohol dependence. Measures. The LR to alcohol was originally evaluated following the consumption of 0.61 g/kg of ethanol at age 20 by determining the levels of change in subjective feelings of intoxication, body sway and several hormones such as cortisol. From the 453 original subjects, 450 completed a face-to-face 10-year follow-up evaluation, and 439 completed the 15-year protocol. Findings. A comparison of the clinical course of 50 alcohol-dependent men with clearly low LR values at age 20 with that for 42 individuals whose LR scores were above the median revealed few differences. Those with a low LR had a slightly earlier age of onset of alcohol dependence (24.8 +/- 3.41 vs. 26.6 +/- 4.48 years), and this Znding was unrelated to the presence of an alcohol-dependent father. Otherwise the membersof the two groups demonstrated a similar course of alcohol dependence. There was no relationship between a low LR at age 20 and either the pattern ofsubstances used or the rate of dependence on illicit drugs. Conclusions. The results indicate that for this sample a low LR to alcohol, while associated with a high risk for alcohol dependence, was not related to most aspects of the course of alcohol problems once dependence developed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:50:17