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Titolo:
Evaluation of the efficacy of the combination of multiple autoantibodies to islet-specific antigens in Korean type 1 diabetic patients
Autore:
Park, Y; Lee, H; Takino, H; Abiru, N; Kawasaki, E; Eisenbarth, GS;
Indirizzi:
Hanyang Univ Hosp, Dept Internal Med, Kuri 471020, Kyunggi Do, South KoreaHanyang Univ Hosp Kuri Kyunggi Do South Korea 471020 nggi Do, South Korea Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea SeoulNatl Univ Seoul South Korea 151 ternal Med, Seoul 151, South Korea Nagasaki Univ, Sch Med, Dept Internal Med 1, Nagasaki 852, Japan Nagasaki Univ Nagasaki Japan 852 ept Internal Med 1, Nagasaki 852, Japan Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Childhood Diabet, Denver, CO 80262 USA
Titolo Testata:
ACTA DIABETOLOGICA
fascicolo: 1, volume: 38, anno: 2001,
pagine: 51 - 56
SICI:
0940-5429(200103)38:1<51:EOTEOT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; PROTEIN-TYROSINE-PHOSPHATASE; CELL ANTIBODIES; MOLECULAR-CLONING; INSULIN; MELLITUS; IDENTIFICATION; IDDM; AUTOANTIGEN; PREDICTION;
Keywords:
type 1 diabetes mellitus; GAD65 antibody; islet cell antibody; ICA512 antibody; Korea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Park, Y Hanyang Univ Hosp, Dept Internal Med, 249-1 Kyomun Dong, Kuri 471020, Kyunggi Do, South Korea Hanyang Univ Hosp 249-1 Kyomun Dong Kuri Kyunggi Do South Korea 471020
Citazione:
Y. Park et al., "Evaluation of the efficacy of the combination of multiple autoantibodies to islet-specific antigens in Korean type 1 diabetic patients", ACT DIABETO, 38(1), 2001, pp. 51-56

Abstract

With the recent cloning and recombinant expression of novel islet autoantigens, it is possible to investigate whether the quantitative expression of autoantibodies to those molecules is correlated with the semiquantitative titration of islet cell antibodies (ICA). To estimate the regional difference in the degree of association between these autoantibodies, autoantibodiesreacting with ICA512/IA-2 (ICA512) and GAD65 in addition to ICA were analyzed in 131 Korean children with type I diabetes. Among the 131 type 1 diabetes patients, 36% was ICA512-positive, 56% was anti-GAD65-positive, and 43%was ICA-positive. However, in a subset of these with recent onset (<1 year), the prevalences of ICA512, anti-GAD65, and ICA were 75%, 75%, and 87.5%,respectively. ICA512 as well as anti-GAD65 were significantly associated with the presence of ICA. Among type 1 diabetes patients, 69% had one or more and 43% had two or more of these autoantibodies. Autoantibodies to ICA512and anti-GAD65 were observed in 40 and in 41 of 56 TCA-positive subjects, respectively. Furthermore, ICA512 or anti-GAD65 were positive in 97% (34 of35) and 100% (22 of 22) of patients with ICA levels <greater than or equalto>20 JDF-u and greater than or equal to 40 JDF-u, respectively. The titerof ICA correlated with those of ICA512 (r=0.41, p<0.001) and anti-GAD65 (r=0.49, p<0.001). Both the prevalences and the titers of ICA512 or anti-GAD65 were strongly con-elated with those of ICA even in Korean type 1 diabetespatients. ICA512 and anti-GAD65 in combination may be considered to be an alternative to ICA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:43:11