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Titolo:
Cholesteryl ester transfer and cholesterol esterification in type 1 diabetes: relationships with plasma glucose
Autore:
Chang, CK; Tso, TK; Snook, JT; Huang, YS; Lozano, RA; Zipf, WB;
Indirizzi:
Ohio State Univ, Nutr Program, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 utr Program, Columbus, OH 43210 USA Fooyin Inst Technol, Dept Nutr & Hlth Sci, Kaohsiung, Taiwan Fooyin Inst Technol Kaohsiung Taiwan Nutr & Hlth Sci, Kaohsiung, Taiwan Shih Chien Univ, Dept Food & Nutr, Taipei, Taiwan Shih Chien Univ TaipeiTaiwan en Univ, Dept Food & Nutr, Taipei, Taiwan Abbott Labs, Ross Prod Div, Med Nutr R&D, Columbus, OH USA Abbott Labs Columbus OH USA oss Prod Div, Med Nutr R&D, Columbus, OH USA Columbus Childrens Hosp, Columbus, OH USA Columbus Childrens Hosp Columbus OH USA Childrens Hosp, Columbus, OH USA
Titolo Testata:
ACTA DIABETOLOGICA
fascicolo: 1, volume: 38, anno: 2001,
pagine: 37 - 42
SICI:
0940-5429(200103)38:1<37:CETACE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFER PROTEIN-CONCENTRATION; HIGH-DENSITY-LIPOPROTEINS; B-CONTAINING LIPOPROTEINS; CORONARY-ARTERY DISEASE; VERY-LOW-DENSITY; SERUM-LIPOPROTEINS; TRANSGENIC MICE; LIPID TRANSFER; A-II; MELLITUS;
Keywords:
type 1 (insulin-dependent) diabetes mellitus; cholesteryl ester transfer protein; lecithin : cholesterol acyltransferase; plasma glucose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Snook, JT Ohio State Univ, Nutr Program, 1787 Neil Ave, Columbus, OH 43210USA Ohio State Univ 1787 Neil Ave Columbus OH USA 43210 OH 43210 USA
Citazione:
C.K. Chang et al., "Cholesteryl ester transfer and cholesterol esterification in type 1 diabetes: relationships with plasma glucose", ACT DIABETO, 38(1), 2001, pp. 37-42

Abstract

The activities of two crucial enzymes of reverse cholesterol transport, cholesterol ester transfer protein (CETP) and lecithin:cholesterol acyltransferase (LCAT), and their relationships with lipid profile and fasting plasmaglucose were examined in 35 type 1 diabetic children. The CETP and LCAT activities were significantly lower (p<0.05) in the 4 subjects with normal fasting plasma glucose levels (<6.39 mmol/l) than in the 28 with high plasma glucose levels (CEPT activity, 10.63+/-3.81 vs. 32.18+/-13.94 nmol/ml h; LCAT activity, 25.52+/-4.53 vs. 39.52+/-12.52 nmol/ml h; both p<0.05). The subjects with high plasma glucose levels also had higher total and LDL-cholesterol than those with normal glucose levels. CETP activity was positively correlated with fasting plasma glucose, CETP concentration, LCAT activity, total cholesterol, free cholesterol, LDL-C, and LDL-cholesteryl ester, whilenegatively correlated with cholesteryl ester to free cholesterol ratio, LDL triglyceride to protein ratio, and LDL triglyceride to cholesteryl ester ratio. LCAT activity was found to positively correlate with CETP activity, total cholesterol, free cholesterol, LDL-C, CETP concentration, and LDL-cholesteryl ester, while it negatively correlated with cholesteryl ester to free cholesterol ratio. The results observed in type 1 diabetic subjects suggest that (I) accelerated LCAT and CETP activities may result in the accumulation of LDL-cholesteryl ester; and (2) fasting plasma glucose may be a major determinant of CETP activity.

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Documento generato il 29/03/20 alle ore 08:37:37