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Titolo:
The effect of sodium heparin on equine articular cartilage
Autore:
McCarthy, HE; Singer, ER; Morel, MCGD;
Indirizzi:
Univ Liverpool, Dept Vet Clin Sci & Anim Husb, Div Equine Studies, Neston CH64 7TE, Cheshire, England Univ Liverpool Neston Cheshire England CH64 7TE 64 7TE, Cheshire, England Univ Wales, Welsh Inst Rural Studies, Aberystwyth SY23 3AL, Ceredigion, Wales Univ Wales Aberystwyth Ceredigion Wales SY23 3AL 3 3AL, Ceredigion, Wales
Titolo Testata:
VETERINARY JOURNAL
fascicolo: 1, volume: 162, anno: 2001,
pagine: 73 - 79
SICI:
1090-0233(200107)162:1<73:TEOSHO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE CALCIUM HEPARIN; INFECTIOUS ARTHRITIS; SEPTIC ARTHRITIS; DEGRADATION; HORSES; PROTEOGLYCAN; THROMBIN; CELLS;
Keywords:
articular cartilage; equine; infectious arthritis; heparin; glycosaminoglycans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: McCarthy, HE Univ Liverpool, Dept Vet Clin Sci & Anim Husb, Div Equine Studies, Neston CH64 7TE, Cheshire, England Univ Liverpool Neston Cheshire England CH64 7TE ire, England
Citazione:
H.E. McCarthy et al., "The effect of sodium heparin on equine articular cartilage", VET J, 162(1), 2001, pp. 73-79

Abstract

This study compared the effect of sodium heparin and gentamicin sulphate on equine articular cartilage (AC) explants in order to investigate the possible use of sodium heparin in the treatment of infectious arthritis. Six concentrations of sodium heparin and gentamicin sulphate were tested. The supernatant and explant digest were assayed for glycosaminoglycan (GAG) content with the dimethyl-methylene blue assay and the per cent loss of GAG was calculated. A significant (P < 0.001) increase in percentage GAG loss was noted for the sodium heparin groups when compared to the control, whilst no significant increase was found among the treatment groups (P= 0.782). For gentamicin, no significant difference in percentage GAG loss was found between the control and three of the five treatment groups (P= 0.667). The percentage GAG loss in the sodium heparin treated AC explants was greater than for any of the gentamicin-treated AC explants. It can be concluded that sodium heparin sulphate stimulates an increase in GAG release from equine articular cartilage explants, though no firm conclusions can be drawn on its use in treating equine infectious arthritis. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:26:30