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Titolo:
Training affects the collagen framework of subchondral bone in foals
Autore:
Brama, PAJ; Bank, RA; Tekoppele, JM; Van Weeren, PR;
Indirizzi:
Univ Utrecht, Fac Vet Med, Dept Equine Sci, NL-3584 CM Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CM 3584 CM Utrecht, Netherlands TNO, Gaubius Lab, Div Vasc & Connect Tissue Res, Leiden, Netherlands TNO Leiden Netherlands v Vasc & Connect Tissue Res, Leiden, Netherlands
Titolo Testata:
VETERINARY JOURNAL
fascicolo: 1, volume: 162, anno: 2001,
pagine: 24 - 32
SICI:
1090-0233(200107)162:1<24:TATCFO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EQUINE ARTICULAR-CARTILAGE; CROSS-LINKING; STRENUOUS EXERCISE; BIOCHEMICAL CHARACTERISTICS; BIOMECHANICAL PROPERTIES; FUNCTIONAL ADAPTATION; PHYSICAL-ACTIVITY; MINERAL DENSITY; CALCIUM INTAKE; AGE;
Keywords:
horse; subchondral bone; training; collagen network;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Brama, PAJ Univ Utrecht, Fac Vet Med, Dept Equine Sci, Yalelaan 12, NL-3584 CM Utrecht, Netherlands Univ Utrecht Yalelaan 12 Utrecht Netherlands NL-3584 CM rlands
Citazione:
P.A.J. Brama et al., "Training affects the collagen framework of subchondral bone in foals", VET J, 162(1), 2001, pp. 24-32

Abstract

Subchondral bone provides structural support to the overlying articular cartilage and plays an important role in osteochondral diseases. There is growing insight that the mechanical features of bone are related to the biochemistry of the collagen network. In this study the effect of exercise on water calcium and the collagen network (total collagen, lysyl-hydroxylation, hydroxylysylpyridinoline, and lysylpyridinoline crosslinks) of subchondral bone at two differently loaded sites (site 1: intermittantly loaded; site 2:constantly loaded) is investigated in foals. Exercise influenced calcium content and levels of both types of crosslinksat site 1, but had no influence on site 2. There was no concomitant increase in lysyl-hydroxylation level with the rise in crosslinks. Levels of lysyl-hydroxylation and lysylpyridinoline crosslinking were lower at site 1 than at site 2. It is concluded that exercise affects the post-translational modifications of the collagen component of subchondral bone. Loading also appears to play a role in site-related topographical differences. The lack ofany relation between the sum of pyridinoline crosslinks and the amount of triple helical hydroxylysine gives support to a recent hypothesis that lysyl-hydroxylation of the triple helix and the telopeptides are under seperatecontrol. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:46:48