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Titolo:
Pharmacological treatment in behavioural medicine: The importance of neurochemistry, molecular biology and mechanistic hypotheses
Autore:
Overall, KL;
Indirizzi:
Univ Penn, Sch Vet Med, Dept Clin Studies, Behav Clin,VHUP, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Clin,VHUP, Philadelphia, PA 19104 USA
Titolo Testata:
VETERINARY JOURNAL
fascicolo: 1, volume: 162, anno: 2001,
pagine: 9 - 23
SICI:
1090-0233(200107)162:1<9:PTIBMT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; FELINE ELIMINATION DISORDERS; CLOMIPRAMINE TREATMENT; DOMINANCE AGGRESSION; PANIC DISORDER; CLINICAL-TRIAL; DOUBLE-BLIND; DOGS; FLUOXETINE; DRUG;
Keywords:
psychopharmacology; tricyclic antidepressant (TCA); selective serotonin re-uptake inhibitor (SSRI); serotonin; 5-HT; gamma amino butyric acid (GABA); norepinephrine (NE); cytosolic response element binding protein (CREB); brain derived neurotrophic factor (BDNF); synaptic plasticity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Overall, KL Univ Penn, Sch Vet Med, Dept Clin Studies, Behav Clin,VHUP, 3850 Spruce St, Philadelphia, PA 19104 USA Univ Penn 3850 Spruce St Philadelphia PA USA 19104 A 19104 USA
Citazione:
K.L. Overall, "Pharmacological treatment in behavioural medicine: The importance of neurochemistry, molecular biology and mechanistic hypotheses", VET J, 162(1), 2001, pp. 9-23

Abstract

Psychopharmacology has become a popular, and sometimes mandatory addition to treatment regimes for canine and feline patients with behavioural problems; however, clients and practitioners should be dissuaded that behaviouraldrugs are 'quick fixes'. Veterinarians should only prescribe psychotropic medication when they have a specific idea of how the mechanism of action ofthe drug will affect the target behaviours associated with a specific diagnosis. The diagnosis must be treated rather than non-specific signs. Newer psychotropic medications demonstrate the extent to which truly abnormal behaviours are dysfunctions of neurochemistry; synaptic or cellular metabolism; or genetic encoding and 'learning', or LTP, hence there is a clear role for the interaction of neuropharmacology and behavioural and environmental modification. Future advances in treatment in behavioural medicine will be pharmacological and neurophysiological. As the field of behavioural medicine expands, its paradigm will enlarge to include combination therapy and the implementation of neuropharmacological intervention as a diagnostic tool. At present, the veterinary practitioner can effectively aid many common behavioural problems using extant drugs to treat animals with true behavioural pathology. Rational pharmacological therapy requires complete medical and behaviouralhistories, requisite laboratory work, complete client understanding and compliance, and an honest and ongoing dialogue between the client and veterinarian that includes frequent follow-ups and re-examinations. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:18:00