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Titolo:
A new experimental model for cryptorchidism: inguinoscrotal approach
Autore:
Dundar, M; Kocak, I; Culhaci, N;
Indirizzi:
Adnan Menderes Univ, Dept Urol, TR-09100 Aydin, Turkey Adnan Menderes Univ Aydin Turkey TR-09100 t Urol, TR-09100 Aydin, Turkey Adnan Menderes Univ, Dept Pathol, TR-09100 Aydin, Turkey Adnan Menderes Univ Aydin Turkey TR-09100 Pathol, TR-09100 Aydin, Turkey
Titolo Testata:
UROLOGICAL RESEARCH
fascicolo: 3, volume: 29, anno: 2001,
pagine: 178 - 181
SICI:
0300-5623(200106)29:3<178:ANEMFC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; UNILATERAL CRYPTORCHIDISM; RATS; FERTILITY; FLUTAMIDE; ANDROGENS;
Keywords:
experimental model; cryptorchidism; inguinoscrotal approach;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Dundar, M Adnan Menderes Univ, Dept Urol, TR-09100 Aydin, Turkey Adnan Menderes Univ Aydin Turkey TR-09100 -09100 Aydin, Turkey
Citazione:
M. Dundar et al., "A new experimental model for cryptorchidism: inguinoscrotal approach", UROL RES, 29(3), 2001, pp. 178-181

Abstract

We investigated the effect of inguinal canal closure as a new mechanicallyinduced cryptorchid rat model. The effectiveness of this new model was evaluated by histopathological examination. Thirty-one 21-day-old Wistar rats were divided into four groups. In groups 1 (n = 6), 2 (n = 6) and 3 (n = 7), unilateral undescended testis was created by performing inguinal canal closure with inguinoscrotal approach. Sham-operated rats were used as controls in group 4 (n = 12). The rats were killed on day 30 after surgery in group 1, day 45 in group 2 and day 60 in group 3. The seminiferous tubular diameter, number of tubules with mature germ cell and Leydig cell clusters wereevaluated. None of the rats were lost during the study period. Signs of infection were not detected in operation site although antibiotics were not used. Overall only three (16%) testes descended into scrotum in study groups. The operation time was 3-4 min for each rat. Histopathological examination revealed detrimental effects of cryptorchidism on testicular growth in study groups. In all groups, except the sham group, the mean tubular diameterand the number of tubules with mature germ cells in the left testicle weresignificantly decreased compared to the right ones. Our findings were in correlation with other experimental studies using different rat models of cryptorchidism. This new model of cryptorchidism is considered to provide a simple and effective technique for investigating the impaired development ofthe testes in cryptorchidism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:46:22