Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Vaccination of cattle against Mycobacterium bovis
Autore:
Buddle, BM;
Indirizzi:
AgRes, Wallaceville Anim Res Ctr, Upper Hutt, New Zealand AgRes Upper Hutt New Zealand ille Anim Res Ctr, Upper Hutt, New Zealand
Titolo Testata:
TUBERCULOSIS
fascicolo: 1-2, volume: 81, anno: 2001,
pagine: 125 - 132
SICI:
1472-9792(2001)81:1-2<125:VOCAMB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURE FILTRATE PROTEINS; TUBERCULOSIS; PROTECTION; VACCINES; BCG; MICE; INFECTION; EFFICACY; ANTIGENS; VACCAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Buddle, BM AgRes, Wallaceville Anim Res Ctr, POB 40063, Upper Hutt, New Zealand AgRes POB 40063 Upper Hutt New Zealand pper Hutt, New Zealand
Citazione:
B.M. Buddle, "Vaccination of cattle against Mycobacterium bovis", TUBERCULOSI, 81(1-2), 2001, pp. 125-132

Abstract

Protection of cattle against bovine tuberculosis by vaccination could be an important control strategy in countries where there is persistence of Mycobacterium bovis infection in wildlife and in developing countries where itis not economical to implement a 'test and slaughter' control programme. Early field trials with Bacille Calmette Guerin (BCG) M. bovis vaccine in cattle produced disappointing results, with induction of tuberculin skin-testreactivity following vaccination and low levels of protection. However, recent studies using a low dose of BCG vaccine in cattle have produced more encouraging results and field trials should now be carried out in developingcountries to determine whether this low dose BCG vaccination strategy willreduce the spread of infection. The options for new candidate tuberculosisvaccines have increased markedly in the last decade with the advent of newattenuated strains of M, bovis, and sub-unit protein and recombinant DNA vaccines. Some of these new types of vaccines have recently been tested in cattle. New attenuated M. bovis vaccines induced greater protection than BCGvaccine in cattle which had been sensitized to environmental mycobacteria prior to vaccination. In contrast, it has proved difficult to stimulate appropriate immune responses in cattle necessary for protection with sub-unit protein and recombinant DNA vaccines and better immunological adjuvants arerequired for these types of vaccines. Progress in the development of new tuberculosis vaccines has been very rapid in the past decade and the prospects for vaccination to control and eradicate bovine tuberculosis are encouraging. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:30:26