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Titolo:
Towards more accurate diagnosis of bovine tuberculosis using defined antigens
Autore:
Pollock, JM; Buddle, BM; Andersen, P;
Indirizzi:
Statens Serum Inst, Dept TB Immunol, DK-2300 Copenhagen S, Denmark StatensSerum Inst Copenhagen Denmark S l, DK-2300 Copenhagen S, Denmark Dept Agr & Rural Dev, Vet Sci Div, Belfast, Antrim, North Ireland Dept Agr& Rural Dev Belfast Antrim North Ireland Antrim, North Ireland AgRes, Wallaceville Anim Res Ctr, Upper Hutt, New Zealand AgRes Upper Hutt New Zealand ille Anim Res Ctr, Upper Hutt, New Zealand
Titolo Testata:
TUBERCULOSIS
fascicolo: 1-2, volume: 81, anno: 2001,
pagine: 65 - 69
SICI:
1472-9792(2001)81:1-2<65:TMADOB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-INTERFERON TEST; MYCOBACTERIUM-BOVIS; ERADICATION PROGRAMS; COMPARATIVE GENOMICS; PROTEIN ANTIGENS; INFECTED CATTLE; T-CELL; BCG; MPB70; SPECIFICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Andersen, P Statens Serum Inst, Dept TB Immunol, Artilleriwej 5, DK-2300 Copenhagen S,Denmark Statens Serum Inst Artilleriwej 5 Copenhagen Denmark Senmark
Citazione:
J.M. Pollock et al., "Towards more accurate diagnosis of bovine tuberculosis using defined antigens", TUBERCULOSI, 81(1-2), 2001, pp. 65-69

Abstract

Diagnostic accuracy is of paramount importance in test-and-slaughter programmes for the eradication of bovine tuberculosis (TB). Currently applied methods, such as in vivo skin testing and in vitro interferon-gamma (IFN-gamma) testing, utilize purified protein derivatives (PPDs), which are poorly-defined mixtures containing many individual antigenic components. It is known that false-positive responses to these reagents can occur in cattle whichare not infected with TB, largely because of that antigenic complexity. This paper reviews recent approaches to the characterization of more precisely defined diagnostic tools which can be used to develop tests with greater specificity. For example, the low mass secreted protein ESAT-6 has been shown to be capable of differentiating TB-infected cattle from those which develop responsiveness to PPD through contact with environmental mycobacteria or vaccination with BCG. The information which has accumulated in recent years has shown that the increased specificity is associated with some decrease in test sensitivity. but the overall advantages of being able to make precise diagnostic decisions will have significant advantages in many situations. (C) 2001 Harcourt Publishers Ltd

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:11:30