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Titolo:
The outcome in myasthenia gravis patients - an eight-year follow-up after finishing immunoabsorption therapy
Autore:
Schneidewind, JM; Zettl, UK; Winkler, RE; Ramlow, W; Tiess, M; Michelsen, A; Hebestreit, G; Prophet, H; Patow, W; Benecke, R;
Indirizzi:
Dialyse Germeinschaft Nord eV, D-18107 Rostock, Germany Dialyse Germeinschaft Nord eV Rostock Germany D-18107 7 Rostock, Germany Univ Rostock, Dept Neurol, Rostock, Germany Univ Rostock Rostock Germany niv Rostock, Dept Neurol, Rostock, Germany
Titolo Testata:
TRANSFUSION AND APHERESIS SCIENCE
fascicolo: 1, volume: 24, anno: 2001,
pagine: 95 - 98
SICI:
1473-0502(200102)24:1<95:TOIMGP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Keywords:
therapeutic apheresis; immunoabsorption; protein A; myasthenia gravis; lymphocytes; thymoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Schneidewind, JM Dialyse Germeinschaft Nord eV, Rigaer Str 21, D-18107 Rostock, Germany Dialyse Germeinschaft Nord eV Rigaer Str 21 Rostock Germany D-18107
Citazione:
J.M. Schneidewind et al., "The outcome in myasthenia gravis patients - an eight-year follow-up after finishing immunoabsorption therapy", TRANSF AP S, 24(1), 2001, pp. 95-98

Abstract

Eight years ago four patients suffering from myasthenia gravis (MG) type Cand E according to Compston with failed drug therapy were treated three times tone patient 11 times) by protein A immunoabsorption (Immunosorb (R) Excorim, Fresenius Hemocare GmbH, StWendel, Germany). No further immunoabsorption treatments have been carried out. In addition, three patients were given a thymectomy. The present status of the patients was checked six and eight years thereafter. We could see a beneficial effect in all MG patients. The patients are fit for work: all have an improved Besinger index. The patients were used as their own controls. A higher anti-AChR-ab level six yearsafter protein A immunoabsorption than at the beginning was seen in all patients combined with a less serious MG. In addition, their immunomodulation could be induced as seen in lymphocyte and inflammatory protein changes during the first 36 days after beginning immunoabsorption treatment. A larger population has to be investigated to verify these results. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 11:17:22