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Titolo:
Longitudinal distribution of ozone and chlorine in the human respiratory tract: Simulation of nasal and oral breathing with the single-path diffusionmodel
Autore:
Bush, ML; Zhang, W; Ben-Jebria, A; Ultman, JS;
Indirizzi:
Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 n, University Pk, PA 16802 USA
Titolo Testata:
TOXICOLOGY AND APPLIED PHARMACOLOGY
fascicolo: 3, volume: 173, anno: 2001,
pagine: 137 - 145
SICI:
0041-008X(20010615)173:3<137:LDOOAC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN AIRWAYS; ABSORPTION; LUNG; DEPOSITION; FLOW;
Keywords:
mathematical modeling; bolus inhalation; air pollutant dosimetry; diffusion-reaction; reactive gas uptake; inhalation toxicology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bush, ML Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA PennState Univ University Pk PA USA 16802 sity Pk, PA 16802 USA
Citazione:
M.L. Bush et al., "Longitudinal distribution of ozone and chlorine in the human respiratory tract: Simulation of nasal and oral breathing with the single-path diffusionmodel", TOX APPL PH, 173(3), 2001, pp. 137-145

Abstract

In the single-path model of the respiratory system, gas transport occurs within a conduit of progressively increasing cross-sectional and surface areas by a combination of flow, longitudinal dispersion, and lateral absorption. The purpose of this study was to use bolus inhalation data previously obtained for chlorine (Cl-2) and for ozone (O-3) to test the predictive capability of the single-path model and to adjust input parameters for applying the model to other exposure conditions. The data, consisting of uptake fraction as a function of bolus penetration volume, were recorded on 10 healthynonsmokers breathing orally as well as nasally at alternative air flows of150, 250, and 1000 ml/s. By employing published data for airway anatomy, gas-phase dispersion coefficients, and gas-phase mass transfer coefficients while neglecting diffusion limitations in the mucus phase, the single-path model was capable of predicting the uptake distribution for O-3 but not thesteeper distribution that was observed for Cl-2. To simultaneously explainthe data for these two gases, it was necessary to increase gas-phase mass transfer coefficients and to include a finite diffusion resistance of O-3 within the mucous layer. The O-3 reaction rate constants that accounted for this diffusion resistance, 2 x 10(6) s(-1) in the mouth and 8 x 10(6) s(-1)in the nose and lower airways, were much greater than previously reported reactivities of individual substrates found in mucus. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:27:50