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Titolo:
Modeling myeloid leukemia tumor suppressor gene inactivation in the mouse
Autore:
Shannon, KM; Le Beau, MM; Largaespada, DA; Killeen, N;
Indirizzi:
Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA Univ Chicago Chicago ILUSA 60637 go, Canc Res Ctr, Chicago, IL 60637 USA Univ Chicago, Hematol Oncol Sect, Dept Med, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 l Sect, Dept Med, Chicago, IL 60637 USA Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 r Canc, Minneapolis, MN 55455 USA Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA Dept Genet Cell Biol& Dev Minneapolis MN USA 55455 eapolis, MN 55455 USA Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 191 - 199
SICI:
1044-579X(200106)11:3<191:MMLTSG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; JUVENILE MYELOMONOCYTIC LEUKEMIA; STEM-CELL DIFFERENTIATION; COLONY-STIMULATING FACTOR; COMMONLY DELETED REGION; NEUROFIBROMATOSIS TYPE-1; MOLECULAR DELINEATION; HEMATOPOIETIC PROGENITORS; RETROVIRAL VECTORS; BONE-MARROW;
Keywords:
myeloid leukemia; nuerofibromatosis; mouse models; tumor suppressor genes; chromosome engineering;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Shannon, KM Univ Calif San Francisco, Dept Pediat, Room HSE-302,513 Parnassus Ave, SanFrancisco, CA 94143 USA Univ Calif San Francisco Room HSE-302,513 Parnassus Ave San Francisco CA USA 94143
Citazione:
K.M. Shannon et al., "Modeling myeloid leukemia tumor suppressor gene inactivation in the mouse", SEM CANC B, 11(3), 2001, pp. 191-199

Abstract

Introducing dominant oncogenic alterations uncovered in human myeloid malignancies into the mouse germline provides a powerful approach for studying leukemogenesis. However, little is known about how gene inactivation contributes to the development of myeloid malignancies. We describe how Nf1 mutant,mice provide one example in which disrupting a tumor suppressor gene has been used to generate an informative murine leukemia model. We also discusshow chromosome engineering technologies are being harnessed to model the segmental deletions found in)myeloid malignancies, and how these approaches can be combined with retrovirally medicated insertional mutagenesis to generate new models and for gene discovery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:36:59