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Titolo:
Epilepsy and pregnancy
Autore:
Crawford, P;
Indirizzi:
Special Ctr Epilepsy, York, N Yorkshire, England Special Ctr Epilepsy York N Yorkshire England York, N Yorkshire, England Leeds Metropolitan Univ, Leeds LS1 3HE, W Yorkshire, England Leeds Metropolitan Univ Leeds W Yorkshire England LS1 3HE kshire, England
Titolo Testata:
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
fascicolo: 3, volume: 10, anno: 2001,
pagine: 212 - 219
SICI:
1059-1311(200104)10:3<212:EAP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-TUBE DEFECTS; ANTIEPILEPTIC DRUGS; ANTICONVULSANT DRUGS; GROWTH-RETARDATION; MINOR ANOMALIES; VALPROIC ACID; FETAL GROWTH; WOMEN; MALFORMATIONS; MOTHERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Crawford, P York Dist Hosp, York YO31 8HE, N Yorkshire, England York Dist Hosp York N Yorkshire England YO31 8HE ire, England
Citazione:
P. Crawford, "Epilepsy and pregnancy", SEIZURE-E J, 10(3), 2001, pp. 212-219

Abstract

Pregnancies in women with epilepsy are high risk and need careful management by both the medical and obstetric teams due to the increased incidence of complications and adverse outcomes of pregnancy. By the time a pregnant woman with epilepsy presents, the foetus is virtually fully formed and the opportunity for altering drug treatment has passed. Women need to be counselled and told to seek advice about their anticonvulsant therapy should they wish to become pregnant. All major anticonvulsant drugs are teratogenic but the main risk to the developing foetus appears tobe when the mother is on polytherapy especially if sodium valproate forms part of the combination. Folate supplements (5 mg) before conception are advisable. There appears to be a minor but significant increased risk of maternal complications in women with epilepsy such as hyperemesis gravidarum, pre-eclampsia and eclampsia, vaginal bleeding and premature labour. Ln the majority of women seizure control will not alter during pregnancy. Oral vitamin K should be given to the mother receiving enzyme-inducing antiepileptic drugs. Post-natal infant development: there is an increased risk of prematurity (9-11%), stillbirth, neonatal and perinatal death, haemorrhagic disease of the newborn, low Apgar scores and low birth weight (7-10%). Breastfeeding: virtually all the anticonvulsant drugs are excreted in breast milk in low concentrations. Feeding difficulties, irritability and lethargy can occur. However, the benefits of breast feeding usually far outweighany minor risks to the baby. (C) 2001 BEA Trading Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:15:07