Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neuroleptics normalize increased release of interleukin-1 beta and tumor necrosis factor-alpha from monocytes in schizophrenia
Autore:
Kowalski, J; Blada, P; Kucia, K; Madej, A; Herman, ZS;
Indirizzi:
Med Univ Silesia, Dept Clin Pharmacol, Katowice, Poland Med Univ Silesia Katowice Poland Dept Clin Pharmacol, Katowice, Poland Med Univ Silesia, Dept Psychiat, Katowice, Poland Med Univ Silesia Katowice Poland lesia, Dept Psychiat, Katowice, Poland
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 50, anno: 2001,
pagine: 169 - 175
SICI:
0920-9964(20010701)50:3<169:NNIROI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; SOLUBLE INTERLEUKIN-2; MAJOR DEPRESSION; PLASMA-LEVELS; LYMPHOCYTE-T; RECEPTORS; BLOOD; BRAIN; CLOZAPINE; MOUSE;
Keywords:
haloperidol; IL-1 beta; monocytes; perazine; schizophrenia; TNF-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kowalski, J Med Univ Silesia, Dept Clin Pharmacol, Katowice, Poland Med Univ Silesia Katowice Poland harmacol, Katowice, Poland
Citazione:
J. Kowalski et al., "Neuroleptics normalize increased release of interleukin-1 beta and tumor necrosis factor-alpha from monocytes in schizophrenia", SCHIZOPHR R, 50(3), 2001, pp. 169-175

Abstract

Some recent reports show that schizophrenia is accompanied by changes in lymphocyte activity. This study investigated the activity of monocytes by determining their release of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). Monocytes were immunomagnetically isolated fromthe peripheral blood of schizophrenic patients before and after neuroleptic medication and stimulated by lipopolisaccharide (LPS) in vitro. The monocytes of schizophrenic patients released significantly higher amounts of IL-1 beta and TNF-alpha than those of healthy controls. Treatment with the typical neuroleptics haloperidol and perazine decreased the release of IL-1 beta and TNF-alpha to the control levels. The study has shown that the activity of monocytes is increased in schizophrenia and that neuroleptic treatment normalizes this activity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:53:17