Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Using biological indices to classify schizophrenia and other psychotic patients
Autore:
Sponheim, SR; Iacono, WG; Thuras, PD; Beiser, M;
Indirizzi:
Vet Affairs Med Ctr, Minneapolis, MN 55417 USA Vet Affairs Med Ctr Minneapolis MN USA 55417 r, Minneapolis, MN 55417 USA Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 sychol, Minneapolis, MN 55455 USA Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ychiat, Minneapolis, MN 55455 USA Clarke Inst Psychiat, Toronto, ON M5T 1R8, Canada Clarke Inst Psychiat Toronto ON Canada M5T 1R8 oronto, ON M5T 1R8, Canada
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 50, anno: 2001,
pagine: 139 - 150
SICI:
0920-9964(20010701)50:3<139:UBITCS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURSUIT EYE TRACKING; NAILFOLD PLEXUS VISIBILITY; FIRST-DEGREE RELATIVES; FIRST-EPISODE; IDENTIFYING SUBTYPES; ANALYTIC APPROACH; RESTING EEG; ABNORMALITIES; HETEROGENEITY; DISORDERS;
Keywords:
genetic vulnerability; nosology; ocular motor function; psychosis; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Sponheim, SR Vet Affairs Med Ctr, 1 Vet Dr, Minneapolis, MN 55417 USA Vet Affairs Med Ctr 1 Vet Dr Minneapolis MN USA 55417 417 USA
Citazione:
S.R. Sponheim et al., "Using biological indices to classify schizophrenia and other psychotic patients", SCHIZOPHR R, 50(3), 2001, pp. 139-150

Abstract

Although classification of mental disorders using more than clinical description would be desirable, there is scant evidence that available laboratory tests (i.e, biological indices) would provide more valid classifications than current diagnostic systems (e,g. DSM-IV). We used cluster analysis of four biological variables to classify 163 psychotic patients and 83 nonpsychiatric comparison subjects, Analyses revealed a three-cluster solution with the first cluster reflecting electrodermal deviance, the second cluster representing nondeviant biological function, and the third cluster reflecting increased nailfold plexus visibility and ocular motor dysfunction. To assess the construct validity of proband clusters we examined ocular motor performance in 156 first-degree relatives as a function of proband cluster membership. First-degree relatives of third cluster probands exhibited worse ocular motor performance than relatives of other cluster probands. Additionally, better classification sensitivity and specificity were obtained for the relatives when they were grouped by proband cluster than by proband DSM-IV diagnosis. When a single proband characteristic (i.e. eyetracking performance) was used to group relatives, classification sensitivity and specificity failed to significantly increase over grouping by proband DSM-TV diagnosis. Multivariate biologically defined clusters may offer an advantage over DSM-TV classification when examining nosology and etiology of psychotic disorders. (C) 2001 Elsevier Science B,V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:45:09