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Titolo:
Creutzfeldt-Jakob disease: The value of MRI.
Autore:
Urbach, H; Paus, S; Tschampa, HJ; Keller, E; Schild, HH;
Indirizzi:
Univ Bonn, Radiol Klin, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 Bonn, Radiol Klin, D-53105 Bonn, Germany Univ Bonn, Neurol Klin, Bonn, Germany Univ Bonn Bonn GermanyUniv Bonn, Neurol Klin, Bonn, Germany
Titolo Testata:
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
fascicolo: 6, volume: 173, anno: 2001,
pagine: 509 - 514
SICI:
1438-9029(200106)173:6<509:CDTVOM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
GER
Soggetto:
DIFFUSION-WEIGHTED MRI; AMYOTROPHIC-LATERAL-SCLEROSIS; MAGNETIC-RESONANCE IMAGES; CLINICAL-DIAGNOSIS; VARIANT; DEGENERATION; CORTEX;
Keywords:
Creutzfeldt-Jakob disease; CJD; magnetic resonance imaging; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Urbach, H Univ Bonn, Radiol Klin, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 nn, Germany
Citazione:
H. Urbach et al., "Creutzfeldt-Jakob disease: The value of MRI.", ROFO-F RONT, 173(6), 2001, pp. 509-514

Abstract

Purpose: To define the role of MRI in the diagnosis of Creutzfeldt-Jakob disease (C]D). Methods: 14 patients with suspected CJD were studied within 3years. MRI findings were correlated with WHO established diagnostic criteria (clinical findings, EEC, CSF with 14-3-3 protein assay). Results: 12 patients had C]D. One patient each suffered from Hashimoto's encephalitis and ALS dementia complex, respectively. Nine of 12 C]D patients had increased signal intensity of the striatum (n = 8), pulvinar thalami (n = 5) and/or cerebellar and cerebral cortex(n = 3), respectively. Signal intensity was most pronounced on FLAIR sequences; six patients were studied with diffusion-weighted MRI and showed impaired diffusion in these areas. Both patients without CJD did not show the abovementioned signal changes (sensitivity 75%, specificity and positive predictive value 100%, respectively). Conclusion: If patients with suspected CJD are studied with FLAIR and diffusion-weightedsequences, this disorder can reliably be proven or ruled out. Typical MRI findings narrow down the differential diagnosis and should be included in the WHO diagnostic criteria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:26:08