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Titolo:
A comparison of surfactant delivery with conventional mechanical ventilation and partial liquid ventilation in meconium aspiration injury
Autore:
Chappell, SE; Wolfson, MR; Shaffer, TH;
Indirizzi:
Temple Univ, Sch Med, Dept Physiol, Resp Physiol Sect, Philadelphia, PA 19140 USA Temple Univ Philadelphia PA USA 19140 ol Sect, Philadelphia, PA 19140 USA Temple Univ, Sch Med, Dept Pediat, Philadelphia, PA 19140 USA Temple UnivPhiladelphia PA USA 19140 Pediat, Philadelphia, PA 19140 USA
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 7, volume: 95, anno: 2001,
pagine: 612 - 617
SICI:
0954-6111(200107)95:7<612:ACOSDW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; EXOGENOUS SURFACTANT; PIGLET MODEL; LUNG INJURY; NEWBORN; RABBITS; PERFLUBRON; INHIBITION; VOLUME;
Keywords:
liquid ventilation; surfactant; meconium aspiration syndrome; perfluorochemicals; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Shaffer, TH Temple Univ, Sch Med, Dept Physiol, Resp Physiol Sect, 3420 N Broad St, Philadelphia, PA 19140 USA Temple Univ 3420 N Broad St Philadelphia PA USA 19140 9140 USA
Citazione:
S.E. Chappell et al., "A comparison of surfactant delivery with conventional mechanical ventilation and partial liquid ventilation in meconium aspiration injury", RESP MED, 95(7), 2001, pp. 612-617

Abstract

The objective of this study was to compare surfactant (SF) distribution and physiological effects after standard SF delivery during conventional mechanical ventilation (CMV) with that using partial liquid ventilation (PLV). A model of meconium aspiration syndrome (MAS) was developed using two groups of adult rats (n = 14). After meconium instillation of 2.5 ml kg(-1) (20%v/w),SF/CMV: (n = 7) CMV and SF/PLV: (n = 7) PLV, received C-14- labeled surfactant (4 ml kg(-1)) delivered intratracheally in four aliquots over 20 min in both groups. Sequential measurements of arterial blood chemistry andlung mechanics were performed in all animals. At the conclusion of experiments, lungs were inflated (30 cmH(2)O), dried, sectioned and evaluated for radioactivity in disintegrations per minute (DPM). Surfactant distribution was improved (P < 0.01) with PLV as compared to CMV with 48.8.% of the pieces vs. 30.9% of the pieces receiving within 25% of the mean amount of surfactant, respectively. Further, regional distribution was also significantly more uniform with PLV than CMV: left vs right (P<less than>0.01) lung and ventral vs. dorsal (P <0.01) regions. Finally, arterial PO2 and ventilation efficiency index were significantly (P<0.01) greater post-treatment in SF/PLV than SF/CMV. These data demonstrate surfactant delivery with LV, as compared to CMV alone, to be an improved method of delivering surfactant in MASand suggest the possible utility of SF/PLV combination therapy for its treatment of other etiologies of neonatal respiratory distress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:58:22