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Titolo:
Effect of inhaled budesonide therapy on lung function in schoolchildren born preterm
Autore:
Pelkonen, AS; Hakulinen, AL; Hallman, M; Turpeinen, M;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Allerg Dis, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 is, FIN-00014 Helsinki, Finland Helsinki City Matern Hosp, Helsinki, Finland Helsinki City Matern Hosp Helsinki Finland tern Hosp, Helsinki, Finland Univ Oulu, SF-90220 Oulu, Finland Univ Oulu Oulu Finland SF-90220Univ Oulu, SF-90220 Oulu, Finland
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 7, volume: 95, anno: 2001,
pagine: 565 - 570
SICI:
0954-6111(200107)95:7<565:EOIBTO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM TREATMENT; BRONCHOPULMONARY DYSPLASIA; FLOW-RATE; BRONCHIAL RESPONSIVENESS; AIRWAY RESPONSIVENESS; PULMONARY SEQUELAE; CHILDREN BORN; ASTHMA; CORTICOSTEROIDS; INFLAMMATION;
Keywords:
inhaled budesonide; lung function; schoolchildren; preterm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Pelkonen, AS Univ Helsinki, Cent Hosp, Dept Allerg Dis, Meilahdentie 2,POB160, Huch 00029, Finland Univ Helsinki Meilahdentie 2,POB 160 Huch Finland 00029 land
Citazione:
A.S. Pelkonen et al., "Effect of inhaled budesonide therapy on lung function in schoolchildren born preterm", RESP MED, 95(7), 2001, pp. 565-570

Abstract

We investigated the effect of inhaled glucocorticoid (GC) on bronchial obstruction and on bronchial lability in schoolchildren born preterm. Twenty-one children with bronchial obstruction, increased responsiveness to a beta (2)-agonist, and/or increased diurnal variation in peak expiratoryflow (PEF) were selected for an open longitudinal study of the value of inhaled GC. None of these children had an earlier diagnosis of asthma or current GC treatment. Eighteen children with median (range) birth weight 1025 (640-1600)g and gestational age 28 (26-35) weeks, age at study 10.1 (7.7-13)years, were treated with inhaled budesonide in initially high (0.8 mgm(-2)day(-1) for 1 month) and subsequently lower dose (0.4mgm(-2)day(-1) for 3 months). Daily symptom scores were recorded. Spirometric values were measured in the clinic at the beginning and end of each treatment period. At home,children used a data storage spirometer. After treatment with budesonide for 4 months, spirometric values in the clinic did not significantly change. The median forced expiratory volume in 1sec (FEV1) was 74% of predicted both at entry and after budesonide treatment. However, the median number of greater than or equal to 20% diurnal change in PEF values at home decreased during treatment. According to the present study, inhaled budesonide for 4 months had no significant effect on basic lung function but may decrease bronchial lability in schoolchildren born preterm.

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Documento generato il 22/02/20 alle ore 21:36:50