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Titolo:
Bone scintigraphy and the added value of SPECT (single photon emission tomography) in detecting skeletal lesions
Autore:
Savelli, G; Maffioli, L; Maccauro, M; De Deckere, E; Bombardieri, E;
Indirizzi:
Ist Nazl Tumori, Div Nucl Med, Milan, Italy Ist Nazl Tumori Milan ItalyIst Nazl Tumori, Div Nucl Med, Milan, Italy Osped Gen, Div Nucl Med, Lecce, Italy Osped Gen Lecce ItalyOsped Gen, Div Nucl Med, Lecce, Italy Leiden Univ, Med Ctr, Div Nucl Med, Leiden, Netherlands Leiden Univ Leiden Netherlands d Ctr, Div Nucl Med, Leiden, Netherlands
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 45, anno: 2001,
pagine: 27 - 37
SICI:
1125-0135(200103)45:1<27:BSATAV>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTATE-SPECIFIC ANTIGEN; RENAL-CELL CARCINOMA; BREAST-CANCER; FOLLOW-UP; NASOPHARYNGEAL CARCINOMA; VERTEBRAL METASTASES; CLINICAL COURSE; SCAN; BODY; DISEASE;
Keywords:
bone neoplasms, radionuclide imaging; bone neoplasms, secondary; bone neoplasms, diagnosis; tomography, emission computed, single photon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Bombardieri, E Ist Nazl Tumori, Div Nucl Med, Milan, Italy Ist Nazl Tumori Milan Italy , Div Nucl Med, Milan, Italy
Citazione:
G. Savelli et al., "Bone scintigraphy and the added value of SPECT (single photon emission tomography) in detecting skeletal lesions", Q J NUCL M, 45(1), 2001, pp. 27-37

Abstract

Skeletal metastases are one of the major clinical problems for the oncologist. Over the last several decades bone scintigraphy has been used extensively in detecting bone involvement since it can provide information about disease location, prognosis and the effectiveness of treatment. Bone scan offers the advantage of total body examination, and images bone lesions earlier than other techniques. In this paper the main clinical problems related to the most common applications of bone scan in breast, prostate, lung cancer and other tumours are discussed. The experience carried out at the National Cancer Institute of Milan by using bone SPECT to detect single bone metastases is reported. One hundred and eighteen patients with bone metastases (from different tumour types: breast, lung, prostate, lymphomas, etc,) werestudied by planar scintigraphy, SPECT and other radiological modalities (CT, MRT or X-rays). The overall performances of bone SPECT were sensitivity:90.5% (19/21), specificity 92.8% (90/97), positive predictive value 73% (19/26), negative predictive value 97.8% (90/92), accuracy 92.4% (109/118). Considering breast cancer, the most frequent pathology in our series, and the lumbar spinal tract, the most common skeletal segment involved, the figures of merit of SPECT were: sensitivity 100% (4/4), specificity 95.3% (41/43), positive predictive value 66.7% (4/6), negative predictive value 100% (41/41), accuracy 95.7% (45/47). In conclusion bone SPECT showed very good performances, in particular improving the predictive value of planar scan in the diagnosis of vertebral metastases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:15:17