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Titolo:
PET imaging of hypoxia
Autore:
Lewis, JS; Welch, MJ;
Indirizzi:
Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Inst Radiol, St Louis, MO 63110 USA
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 45, anno: 2001,
pagine: 183 - 188
SICI:
1125-0135(200106)45:2<183:PIOH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; ZINC-62 COPPER-62 GENERATOR; TUMOR HYPOXIA; IN-VITRO; ISCHEMIC MYOCARDIUM; MURINE FIBROSARCOMA; 9L GLIOSARCOMA; COMET ASSAY; BLOOD-FLOW; CELLS;
Keywords:
cell hypoxia; neoplasms, radionuclide imaging; tomography, emission computed radiopharmaceuticals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Welch, MJ Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, Campus Box 8225,510 S Kingshighway Blvd, St Louis, MO 63110 USA Washington Univ Campus Box 8225,510 S Kingshighway Blvd St Louis MO USA 63110
Citazione:
J.S. Lewis e M.J. Welch, "PET imaging of hypoxia", Q J NUCL M, 45(2), 2001, pp. 183-188

Abstract

Hypoxia in tumors has been related to poor response to conventional therapies. This paper will discuss the methods, both invasive and non-invasive, used to determine hypoxia levels within tumors. PET imaging;with two lead compounds F-18-fluoromisonidazole ((FMISO)-F-18) and Cu(II)-diacetyl-bis(N-4-methylthiosemicarbazone (Cu-ATSM) and their relative effectiveness in delineating hypoxic regions will be discussed. The advantages of Cu-ATSM-PET over existing imaging agents will be discussed along with its potential application as a direct-and/or surrogate marker for the determination of oncological hypoxia in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:18:04