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Titolo:
Tumor angiogenesis targeting using imaging agents
Autore:
Weber, WA; Haubner, R; Vabuliene, E; Kuhnast, B; Wester, HJ; Schwaiger, M;
Indirizzi:
Tech Univ Munich, Dept Nucl Med, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 Nucl Med, D-8000 Munich, Germany
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 45, anno: 2001,
pagine: 179 - 182
SICI:
1125-0135(200106)45:2<179:TATUIA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; GROWTH;
Keywords:
magnetic resonance imaging; radionuclide imaging; angiogenesis inhibitors; tomography, emission computed; ultrasonography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Weber, WA Klinikum Rechts Isar, Nukl Med Klin, Ismaningerstr 22, D-81675 Munich, Germany Klinikum Rechts Isar Ismaningerstr 22 Munich Germany D-81675 ny
Citazione:
W.A. Weber et al., "Tumor angiogenesis targeting using imaging agents", Q J NUCL M, 45(2), 2001, pp. 179-182

Abstract

The inhibition of tumor induced angiogenesis is an emerging therapeutic strategy in clinical oncology aimed at halting cancer progression by suppressing tumor blood supply. As anti-angiogenic therapy is primarily cytostatic and not cytotoxic, the established criteria for assessing tumor response tochemo- and radiotherapy cannot be applied to anti-angiogenic therapy. Therefore, functional and molecular parameters for imaging of tumor angiogenesis are being intensively studied. Computed tomography, magnetic resonance imaging, ultrasound and scintigraphic techniques can assess changes in vascular permeability and tumor blood now during anti-angiogenic therapy. Scintigraphic techniques, especially positron emission tomography (PET), may be used to monitor the consequences of anti-angiogenic therapy on tumor cell metabolism, proliferation and apoptosis. The high sensitivity of PET which allows measurements of tracer concentrations in the picomolar range is promising for the visualization of specific molecular targets prior to therapy thus identifying patients most likely benefit from a particular form of anti-angiogenic therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 16:04:35