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Titolo:
Evaluation of alternative approaches for imaging cellular growth
Autore:
Krohn, KA;
Indirizzi:
Univ Washington, Imaging Res Lab, Div Nucl Med, Seattle, WA 98195 USA UnivWashington Seattle WA USA 98195 Div Nucl Med, Seattle, WA 98195 USA
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 45, anno: 2001,
pagine: 174 - 178
SICI:
1125-0135(200106)45:2<174:EOAAFI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; PROLIFERATION IN-VIVO; KINETIC-ANALYSIS; THYMIDINE UPTAKE; BRAIN-TUMORS; F-18 FLT; PET; RADIOSYNTHESIS; VALIDATION;
Keywords:
tomography, emission computed; radiopharmaceuticals; DNA; thymidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Krohn, KA Univ Washington, Imaging Res Lab, Div Nucl Med, Box 356004, Seattle, WA 98195 USA Univ Washington Box 356004 Seattle WA USA 98195 le, WA 98195 USA
Citazione:
K.A. Krohn, "Evaluation of alternative approaches for imaging cellular growth", Q J NUCL M, 45(2), 2001, pp. 174-178

Abstract

Uncontrolled growth is a characteristic of malignant tumors. Histochemicaltechniques to measure tumor growth rate in tissue specimens have proved useful but are limited because of sampling and the difficulty of following response to therapy. PET imaging offers the opportunity to measure tumor growth non-invasively and repeatedly as an early assessment of response to therapy. Measuring cellular growth instead of energy metabolism offers significant advantages in evaluating therapy. The rationale is that a cell's biosynthetic machinery, rather than its fuelling process, is more susceptible to cancer therapy. Cytostatic agents may not reduce the quantity of-viable tumor; so imaging a change in cellular proliferation may be the only effectiveway to assess the response to therapy. Radiopharmaceuticals to image growth include labeled amino acids, Lipid precursors, and nucleosides. The biochemical characteristic that most uniquely distinguishes successfully treatedcancer cells is that they no longer synthesize DNA and no longer divide, Thus imaging with labeled thymidine, which is incorporated into DNA hut not into RNA, provides definitive evidence of a cell that is proliferating and,therefore, whether it has responded to treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 07:32:24