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Titolo:
Brain radioligands - State of the art and new trends
Autore:
Halldin, C; Gulyas, B; Langer, O; Farde, L;
Indirizzi:
Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Sect, S-17176 Stockholm, Sweden
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 45, anno: 2001,
pagine: 139 - 152
SICI:
1125-0135(200106)45:2<139:BR-SOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; LIVING HUMAN-BRAIN; NICOTINIC ACETYLCHOLINE-RECEPTORS; CENTRAL BENZODIAZEPINE RECEPTORS; RESEARCH-AND-DEVELOPMENT; DOPAMINE D-2 RECEPTORS; MONOAMINE-OXIDASE-A; NOR-BETA-CIT; F-18 P-MPPF; IN-VIVO;
Keywords:
tomography, emission computed; tomography, emission computed, single photon radiopharmaceuticals; brain; carbon radioisotopes; fluorine radioisotopes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
150
Recensione:
Indirizzi per estratti:
Indirizzo: Halldin, C Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 76 Stockholm, Sweden
Citazione:
C. Halldin et al., "Brain radioligands - State of the art and new trends", Q J NUCL M, 45(2), 2001, pp. 139-152

Abstract

Non-invasive radioligand imaging methods for brain receptor studies use either short-lived positron-emitting radionuclides such as C-11 and F-18 for positron emission tomography (PET) or single photon-emitting radionuclides such as I-123 for single photon emission computed tomography (SPECT). PET and SPECT use radioligands which are injected intravenously into experimental animals, human volunteers or patients. The main applications of radioligands in brain research concern human neuropsychopharmacology and the discovery and development of novel drugs to be used in the therapy of neurologicaland psychiatric disorders. A basic problem in PET and SPECT brain receptorstudies is the lack of useful radioligands with appropriate binding characteristics. Prerequisite criteria need to be satisfied for a radioligand to reveal target binding sites in vivo. This section will discuss these important criteria and also review recent examples in neuroreceptor radioligand development such as selective radioligands for brain monoamine transporters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:13:27