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Titolo:
Vulnerability of Positron Emission Tomography radiotracers to endogenous competition - New insights
Autore:
Laruelle, M; Huang, Y;
Indirizzi:
Columbia Univ, New York State Psychiat Inst, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USA Columbia Univ New York NY USA 10032 l Phys & Surg, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Dept Radiol, New York, NY 10032 USA
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 45, anno: 2001,
pagine: 124 - 138
SICI:
1125-0135(200106)45:2<124:VOPETR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DOPAMINE RELEASE; C-11 RACLOPRIDE BINDING; IN-VIVO BINDING; MUSCARINIC CHOLINERGIC RECEPTOR; AGONIST-INDUCED DESENSITIZATION; RHESUS-MONKEY BRAIN; STRIATAL DOPAMINE; SYNAPTIC DOPAMINE; INVIVO BINDING; RAT-BRAIN;
Keywords:
tomography, emission computed; tomography, emission computed, single photon dopamine; brain; receptors, dopamine D2; radiopharmaceuticals;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
151
Recensione:
Indirizzi per estratti:
Indirizzo: Laruelle, M Columbia Univ, New York State Psychiat Inst, Dept Psychiat, Coll Phys & Surg, 1051 Riverside Dr,Unit 31, New York, NY 10032 USA Columbia Univ 1051 Riverside Dr,Unit 31 New York NY USA 10032
Citazione:
M. Laruelle e Y. Huang, "Vulnerability of Positron Emission Tomography radiotracers to endogenous competition - New insights", Q J NUCL M, 45(2), 2001, pp. 124-138

Abstract

PET and SPECT neuroreceptor imaging techniques combined with pharmacological challenges have been introduced to measure acute fluctuations of synaptic dopamine (DA) concentrations in the living human brain, Changes in the tit vivo binding of radioligands following manipulation of transmitter levelsare generally believed to be driven by binding competition between the radio-ligand and neurotransmitter. This imaging modality has been very successful in the study of DA transmission at D2 receptors. Yet, the extension of this technique to the study of other neurotransmitter systems has proven difficult, This paper reviews recent evidence: suggesting that simple bindingcompetition might not be the only phenomenon regulating transmitter-radioligand interactions in vivo, and examines emerging data indicating that receptor trafficking might also be involved, A better understanding of the mechanisms underlying these interactions should facilitate the development of PET and SPECT radiotracers suitable for the reporting of synaptic transmitter levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:17:08