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Titolo:
Contextual control over the expression of fear in rats conditioned under abenzodiazepine
Autore:
Harris, JA; Westbrook, RF;
Indirizzi:
Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 l, Sydney, NSW 2052, Australia
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 156, anno: 2001,
pagine: 92 - 97
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATENT INHIBITION; INDUCED AMNESIA; ACQUISITION; PERFORMANCE; EXTINCTION; RETENTION; AVOIDANCE; MIDAZOLAM; IMPAIRS;
Keywords:
midazolam; amnesia; freezing; extinction; latent inhibition; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Westbrook, RF Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 2052, Australia
Citazione:
J.A. Harris e R.F. Westbrook, "Contextual control over the expression of fear in rats conditioned under abenzodiazepine", PSYCHOPHAR, 156(1), 2001, pp. 92-97

Abstract

Rationale: Benzodiazepines disrupt fear conditioning, but this disruption is context-specific: if rats have been conditioned under a benzodiazepine, their fear is recovered if they are tested in a different context. The present experiments investigated how the conditioning context controls fear in rats conditioned under a benzodiazepine. Objectives: The experiments had three aims: (I) to replicate the finding that fear is recovered when rats aretested in a different context, (2) to test whether the conditioning context reduces fear generally or only for the specific stimulus conditioned in that context and (3) to test whether latent inhibition of the conditioning context reduces its control over fear. Methods: Rats were injected with the benzodiazepine midazolam (1.25 mg/kg) or saline and exposed to a conditioned stimulus (CS) and shock in a distinctive chamber. Latent inhibition of the chamber was induced by extensively preexposing the rats to the chamber. The day after conditioning, fear was assessed by presenting the CS while rats were in either the conditioning chamber or a different chamber. Results: The midazolam-induced reduction of fear was reversed (i.e. fear was partially recovered) if rats were tested in the different context, and was completely prevented if the conditioning context had been latently inhibited. These two effects were not additive since, when the conditioning context had been latently inhibited, rats showed less fear in the different context than in the conditioning context. Conclusions: We argue that midazolam does not disrupt conditioning, but imbues the conditioning context with control overretrieval of the CS-shock association. In this regard, the effects of midazolam closely parallel those of extinction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 11:01:46