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Titolo:
Substantia nigra pars reticulata is a highly potent site of action for thebehavioral effects of the D1 antagonist SCH 23390 in the rat
Autore:
Trevitt, JT; Carlson, BB; Nowend, K; Salamone, JD;
Indirizzi:
Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA Univ Connecticut Storrs CT USA 06269 , Dept Psychol, Storrs, CT 06269 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 156, anno: 2001,
pagine: 32 - 41
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS DOPAMINE; VENTROLATERAL STRIATAL DOPAMINE; INDUCED LOCOMOTOR-ACTIVITY; EXTRAPYRAMIDAL MOTOR FUNCTION; TREMULOUS JAW MOVEMENTS; VENTRAL TEGMENTAL AREA; BASAL GANGLIA; AUTORADIOGRAPHIC LOCALIZATION; AGONIST SKF-82958; OPERANT-BEHAVIOR;
Keywords:
dopamine; receptor; motor; operant; basal ganglia; parkinson; GABA; nucleus accumbens; neostriatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Salamone, JD Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA Univ Connecticut Storrs CT USA 06269 l, Storrs, CT 06269 USA
Citazione:
J.T. Trevitt et al., "Substantia nigra pars reticulata is a highly potent site of action for thebehavioral effects of the D1 antagonist SCH 23390 in the rat", PSYCHOPHAR, 156(1), 2001, pp. 32-41

Abstract

Rationale: Considerable evidence indicates that dopaminergic drugs, including drugs that act on DI receptors, exert their effects by actions on forebrain dopamine terminal regions. Nevertheless, anatomical studies also have demonstrated that there is a high concentration of D1 receptors in the substantia nigra pars reticulata (SNr). The D1 receptors in SNr are located largely on the terminals of gamma -aminobutyric acid (GABA)-ergic striatonigral neurons. The present studies were undertaken to determine whether the D1 antagonist SCH 23390 was effective if locally injected into SNr and to compare the results of SNr injections with those obtained from other brain sites. Fixed ratio 5 (FR5) lever pressing and open-field locomotion were used as the behavioral tests because these tasks are sensitive to systemic SCH 23390. Methods: Rats received bilateral implantations of guide cannulae into either nucleus accumbens, neostriatum, SNr, or control sites in the cortex or brainstem. Rats in the FR5 study were trained prior to surgery. All ratsreceived one of the following local injections (0.5 mul per side): vehicle, 0,25, 0,5, 1.0, or 2.0 mug SCH 23390. Results: In the FR5 study, the SNr was by far the most potent site for suppression of lever pressing, with an ED50 (dose that produces half maximal response) of 0.33 mug per side. Nucleus accumbens and neostriatum injections were less potent than those in SNr,but more potent than injections into the control regions. With open field locomotion, the SNr, nucleus accumbens, and neostriatum were approximately equipotent sites, and all three were more potent than the control sites. Conclusions: SNr was a very potent site for suppression of lever pressing andopen-field locomotion. These data suggest that D1 antagonists have multiple sites of action, including not only the forebrain dopamine terminal regions but also the SNr, It is possible that blockade of SNr D1 receptors modulates GABA release from striatonigral neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:48:19