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Titolo:
Spectrin and ankyrin-based pathways: Metazoan inventions for integrating cells into tissues
Autore:
Bennett, V; Baines, AJ;
Indirizzi:
Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 oward Hughes Med Inst, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Cell Biol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Med Ctr, Dept Biochem, Durham, NC 27710 USA Univ Kent, Dept Biosci, Canterbury, Kent, England Univ Kent Canterbury Kent England Dept Biosci, Canterbury, Kent, England
Titolo Testata:
PHYSIOLOGICAL REVIEWS
fascicolo: 3, volume: 81, anno: 2001,
pagine: 1353 - 1392
SICI:
0031-9333(200107)81:3<1353:SAAPMI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; HUMAN-ERYTHROCYTE SPECTRIN; ACTIN-BINDING DOMAIN; DROSOPHILA BETA-SPECTRIN; MEMBRANE-ASSOCIATED PROTEIN; PLECKSTRIN HOMOLOGY DOMAIN; KIDNEY EPITHELIAL-CELLS; T-LYMPHOMA CELLS; LI-TAI-SHAO; INSERTION DELETION MUTATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
455
Recensione:
Indirizzi per estratti:
Indirizzo: Bennett, V Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 s Med Inst, Durham, NC 27710 USA
Citazione:
V. Bennett e A.J. Baines, "Spectrin and ankyrin-based pathways: Metazoan inventions for integrating cells into tissues", PHYSIOL REV, 81(3), 2001, pp. 1353-1392

Abstract

The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided biologists with a set of interacting proteins with diverse roles in organization and survival of cells in metazoan organisms. This review deals with the molecular physiology of spectrin, ankyrin, which links spectrin to the anion exchanger, and two spectrin-associated proteins that promote spectrin interactions with actin: adducin and protein 4.1. The lack of essential functions for these proteins in generic cells grown in culture andthe absence of their genes in the yeast genome have, until recently, limited advances in understanding their roles outside of erythrocytes. However, completion of the genomes of simple metazoans and application of homologousrecombination in mice now are providing the first glimpses of the full scope of physiological roles for spectrin, ankyrin, and their associated proteins. These functions now include targeting of ion channels and cell adhesion molecules to specialized compartments within the plasma membrane and endoplasmic reticulum of striated muscle and the nervous system, mechanical stabilization at the tissue level based on transcellular protein assemblies, participation in epithelial morphogenesis, and orientation of mitotic spindles in asymmetric cell divisions. These studies, in addition to stretching the erythrocyte paradigm beyond recognition, also are revealing novel cellular pathways essential for metazoan life. Examples are ankyrin-dependent targeting of proteins to excitable membrane domains in the plasma membrane andthe Ca2+ homeostasis compartment of the endoplasmic reticulum. Exciting questions for the future relate to the molecular basis for these pathways andtheir roles in a clinical context, either as the basis for disease or morepositively as therapeutic targets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 11:58:02